反应条件
1: Et3N, 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 4 h / Ambient temperature 2: 92 percent / p-TsOH / CH2Cl2 / 12 h / Ambient temperature 3: 39 percent / n-Bu3SnH, azobis(isobutyronitrile) (AIBN) / benzene / 1 h / Heating 4: 1.) p-toluenesulfinic acid, 2.) Et3N, 4-(N,N-dimethylamino)pyridine / 1.) CH3CN, H2O, RT, 48 h, 2.) CH2Cl2, 3 h 5: 1.) ozone, oxygen, 2.) dimethyl sulfide / 1.) CH2Cl2, 2.) 10 h 6: NaBH4 / methanol / 1 h / -40 °C 7: 93 percent / pyridine, 4-(N,N-dimethylamino)pyridine / 27 h 8: 50percent methanolic ammonia / 4 h 9: 67 percent / pyridine / 27 h 11: 97 percent / Lawesson's reagent / toluene / 1 h / Heating 12: 96 percent / W-2 Raney Ni / ethanol / 1 h / Heating 13: 63 percent / aq. MeNH2 / methanol / 46 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 26 p. 6022 - 6030
