1: 98 percent / Cl2(PCy3)2RuCHPh; ethylene; Pb(OAc)4 / CH2Cl2 / 14 h / 20 °C 2: tetrahydrofuran / 8 h / 0 - 55 °C 3: 2.19 g / aq. NaOH; aq. H2O2 / ethanol / 1 h / Heating 4: K2HPO4*3H2O; Na/Hg / methanol / 2 h / Heating 5: 2.35 g / aq. NaOH / CH2Cl2 / 1 h 6: 98 percent / Et3N / CH2Cl2 / 2 h / 0 - 20 °C 7: 95 percent / Pd(OAc)2; polymer-bound triphenylphosphine; Et3N / dimedone / tetrahydrofuran / 6 h / 20 - 50 °C 8: AD-mix-α; MeSO2NH2; H2O / 2-methyl-propan-2-ol / 168000 h / 3 - 6 °C 9: TBAF / tetrahydrofuran / 24 h / 20 °C 10: 291 mg / DMAP / CH2Cl2 / 20 °C 11: 96 percent / Amberlite IRA-401(OH) / methanol / 2 h / 20 °C View Scheme

1: hydroquinine 1,4-phthalazinediyl diether; K3Fe(CN)6; K2OsO4*2H2O / K2CO3; methanesulfonamide / H2O; 2-methyl-propan-2-ol / 168 h / 4 °C 2: 60 mg / p-toluenesulfonic acid / CH2Cl2 / 3 h / 20 °C 3: 100 percent / H2; palladium(II) chloride / methanol / 0.5 h / 20 °C 4: 94.3 percent / hydrochloric acid / H2O; tetrahydrofuran / 20 h / 20 °C View Scheme

1.1: KHMDS / toluene / 0.08 h / 0 °C 1.2: 2.76 g / toluene / 3 h / 0 - 20 °C 2.1: 88.2 percent / p-toluenesulfonic acid monohydrate / 72 h / 105 °C 3.1: 98 percent / triethylamine / tetrahydrofuran / 24 h / 20 °C 4.1: 95.2 percent / benzylidene-bis(tricyclohexylphosphine)dichlororuthenium / CH2Cl2 / 20 h / Heating 5.1: 74.2 percent / sodium hydride; tetrabutylammonium iodide / tetrahydrofuran / 48 h / 20 °C 6.1: 88.1 percent / trifluoroacetic acid; anisole / CH2Cl2 / 1.5 h / 20 °C 7.1: triphenylphosphine; carbon tetrabromide / CH2Cl2 / 0.17 h / 0 °C 7.2: 73.7 percent / triethylamine / CH2Cl2 / 120 h / 4 °C 8.1: hydroquinine 1,4-phthalazinediyl diether; K3Fe(CN)6; K2OsO4*2H2O / K2CO3; methanesulfonamide / H2O; 2-methyl-propan-2-ol / 168 h / 4 °C 9.1: 60 mg / p-toluenesulfonic acid / CH2Cl2 / 3 h / 20 °C 10.1: 100 percent / H2; palladium(II) chloride / methanol / 0.5 h / 20 °C 11.1: 94.3 percent / hydrochloric acid / H2O; tetrahydrofuran / 20 h / 20 °C View Scheme

1.1: triphenylphosphine; carbon tetrabromide / CH2Cl2 / 0.17 h / 0 °C 1.2: 73.7 percent / triethylamine / CH2Cl2 / 120 h / 4 °C 2.1: hydroquinine 1,4-phthalazinediyl diether; K3Fe(CN)6; K2OsO4*2H2O / K2CO3; methanesulfonamide / H2O; 2-methyl-propan-2-ol / 168 h / 4 °C 3.1: 60 mg / p-toluenesulfonic acid / CH2Cl2 / 3 h / 20 °C 4.1: 100 percent / H2; palladium(II) chloride / methanol / 0.5 h / 20 °C 5.1: 94.3 percent / hydrochloric acid / H2O; tetrahydrofuran / 20 h / 20 °C View Scheme

1.1: 88.2 percent / p-toluenesulfonic acid monohydrate / 72 h / 105 °C 2.1: 98 percent / triethylamine / tetrahydrofuran / 24 h / 20 °C 3.1: 95.2 percent / benzylidene-bis(tricyclohexylphosphine)dichlororuthenium / CH2Cl2 / 20 h / Heating 4.1: 74.2 percent / sodium hydride; tetrabutylammonium iodide / tetrahydrofuran / 48 h / 20 °C 5.1: 88.1 percent / trifluoroacetic acid; anisole / CH2Cl2 / 1.5 h / 20 °C 6.1: triphenylphosphine; carbon tetrabromide / CH2Cl2 / 0.17 h / 0 °C 6.2: 73.7 percent / triethylamine / CH2Cl2 / 120 h / 4 °C 7.1: hydroquinine 1,4-phthalazinediyl diether; K3Fe(CN)6; K2OsO4*2H2O / K2CO3; methanesulfonamide / H2O; 2-methyl-propan-2-ol / 168 h / 4 °C 8.1: 60 mg / p-toluenesulfonic acid / CH2Cl2 / 3 h / 20 °C 9.1: 100 percent / H2; palladium(II) chloride / methanol / 0.5 h / 20 °C 10.1: 94.3 percent / hydrochloric acid / H2O; tetrahydrofuran / 20 h / 20 °C View Scheme

1: 98 percent / 2,6-lutidine / CH2Cl2 / 20 °C 2: 98 percent / Cl2(PCy3)2RuCHPh; ethylene; Pb(OAc)4 / CH2Cl2 / 14 h / 20 °C 3: tetrahydrofuran / 8 h / 0 - 55 °C 4: 2.19 g / aq. NaOH; aq. H2O2 / ethanol / 1 h / Heating 5: K2HPO4*3H2O; Na/Hg / methanol / 2 h / Heating 6: 2.35 g / aq. NaOH / CH2Cl2 / 1 h 7: 98 percent / Et3N / CH2Cl2 / 2 h / 0 - 20 °C 8: 95 percent / Pd(OAc)2; polymer-bound triphenylphosphine; Et3N / dimedone / tetrahydrofuran / 6 h / 20 - 50 °C 9: AD-mix-α; MeSO2NH2; H2O / 2-methyl-propan-2-ol / 168000 h / 3 - 6 °C 10: TBAF / tetrahydrofuran / 24 h / 20 °C 11: 291 mg / DMAP / CH2Cl2 / 20 °C 12: 96 percent / Amberlite IRA-401(OH) / methanol / 2 h / 20 °C View Scheme

1: 98 percent / Et3N / CH2Cl2 / 2 h / 0 - 20 °C 2: 95 percent / Pd(OAc)2; polymer-bound triphenylphosphine; Et3N / dimedone / tetrahydrofuran / 6 h / 20 - 50 °C 3: AD-mix-α; MeSO2NH2; H2O / 2-methyl-propan-2-ol / 168000 h / 3 - 6 °C 4: TBAF / tetrahydrofuran / 24 h / 20 °C 5: 291 mg / DMAP / CH2Cl2 / 20 °C 6: 96 percent / Amberlite IRA-401(OH) / methanol / 2 h / 20 °C View Scheme

1: K2HPO4*3H2O; Na/Hg / methanol / 2 h / Heating 2: 2.35 g / aq. NaOH / CH2Cl2 / 1 h 3: 98 percent / Et3N / CH2Cl2 / 2 h / 0 - 20 °C 4: 95 percent / Pd(OAc)2; polymer-bound triphenylphosphine; Et3N / dimedone / tetrahydrofuran / 6 h / 20 - 50 °C 5: AD-mix-α; MeSO2NH2; H2O / 2-methyl-propan-2-ol / 168000 h / 3 - 6 °C 6: TBAF / tetrahydrofuran / 24 h / 20 °C 7: 291 mg / DMAP / CH2Cl2 / 20 °C 8: 96 percent / Amberlite IRA-401(OH) / methanol / 2 h / 20 °C View Scheme

1: 95 percent / Pd(OAc)2; polymer-bound triphenylphosphine; Et3N / dimedone / tetrahydrofuran / 6 h / 20 - 50 °C 2: AD-mix-α; MeSO2NH2; H2O / 2-methyl-propan-2-ol / 168000 h / 3 - 6 °C 3: TBAF / tetrahydrofuran / 24 h / 20 °C 4: 291 mg / DMAP / CH2Cl2 / 20 °C 5: 96 percent / Amberlite IRA-401(OH) / methanol / 2 h / 20 °C View Scheme

1.1: 88.1 percent / trifluoroacetic acid; anisole / CH2Cl2 / 1.5 h / 20 °C 2.1: triphenylphosphine; carbon tetrabromide / CH2Cl2 / 0.17 h / 0 °C 2.2: 73.7 percent / triethylamine / CH2Cl2 / 120 h / 4 °C 3.1: hydroquinine 1,4-phthalazinediyl diether; K3Fe(CN)6; K2OsO4*2H2O / K2CO3; methanesulfonamide / H2O; 2-methyl-propan-2-ol / 168 h / 4 °C 4.1: 60 mg / p-toluenesulfonic acid / CH2Cl2 / 3 h / 20 °C 5.1: 100 percent / H2; palladium(II) chloride / methanol / 0.5 h / 20 °C 6.1: 94.3 percent / hydrochloric acid / H2O; tetrahydrofuran / 20 h / 20 °C View Scheme