1-戊基-1H-吲哚-3-羧酸合成路线 （共 8 条）
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / -10 - 20 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere View Scheme
参考文献
Blaazer, Antoni R.; Lange, Jos H.M.; Van Der Neut, Martina A.W.; Mulder, Arie; Den Boon, Femke S.; Werkman, Taco R.; Kruse, Chris G.; Wadman, Wytse J.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5086 - 5098
反应条件
sodium hydride in hexane; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Randox Laboratories Ltd.; Fitzgerald, Stephen Peter; Innocenzi, Paul John; Lowry, Philip Andrew; McConnell, Ivan Robert; Benchikh, Elouard
Patent: EP2698385 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
potassium hydroxide in methanol; toluene
2 h; Inert atmosphereReflux;
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 16 h / 0 - 20 °C / Inert atmosphere
2.1: potassium hydroxide / ethanol; water / 20 - 75 °C
View Scheme
参考文献
Blaazer, Antoni R.; Lange, Jos H.M.; Van Der Neut, Martina A.W.; Mulder, Arie; Den Boon, Femke S.; Werkman, Taco R.; Kruse, Chris G.; Wadman, Wytse J.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5086 - 5098
反应条件
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 20 °C / |Inert atmosphere
1.2: 0 - 20 °C / |Inert atmosphere
2.1: mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / |Inert atmosphere
3.1: potassium hydroxide / toluene; methanol / 2 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
反应条件
1: mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / |Inert atmosphere
2: potassium hydroxide / toluene; methanol / 2 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 16 h / 0 - 20 °C / Inert atmosphere
2.1: potassium hydroxide / ethanol; water / 20 - 75 °C
View Scheme
参考文献
Blaazer, Antoni R.; Lange, Jos H.M.; Van Der Neut, Martina A.W.; Mulder, Arie; Den Boon, Femke S.; Werkman, Taco R.; Kruse, Chris G.; Wadman, Wytse J.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5086 - 5098
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / |Inert atmosphere
2: triethylamine / dichloromethane / 14 h / |Inert atmosphere
View Scheme
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
