(5-氯吡嗪-2-基)甲醇合成路线 （共 5 条）
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran T=0°C; 2 h; 2: With methanol
参考文献
IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y.; SPROTT, Kevin
Patent: WO2012/88469 A1, 2012 ;
Location in patent: Page/Page column 151-152 ;
WO 2012/088469 A1
反应条件
methanol; sodium tetrahydroborate T=0 - 20°C; 3 h;
参考文献
WO2009/134668 A2, ;
Page/Page column 29; 30 ;
WO 2009/134668 A2
反应条件
sodium tetrahydroborate in 1,4-dioxane; water T=10 - 20°C;
参考文献
Kmentova, Iveta; Sutherland, Hamish S.; Palmer, Brian D.; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.; Thompson, Andrew M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 23 p. 8421 - 8439
参考文献
WO2011/14774 A1, ;
Page/Page column 23 ;
反应条件
1: diethyl ether; methanol / 0.5 h 2: diisobutylaluminium hydride / tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
WO2012/88469 A1, ;
WO 2012/088469 A1
