6-甲氧基-3-硝基-2-(三氟甲基)吡啶合成路线 （共 4 条）
反应条件
1: With potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=125°C; 13 h; 2: With ammonia; ammonium chloride in water; N,N-dimethyl-formamide T=20°C; 1.5 h;
参考文献
EP2128158 A1, ;
Page/Page column 20-21 ;
EP 2128158 A1
反应条件
copper in isobutyramide T=20 - 100°C; 8 h;
参考文献
WO2004/62665 A1, ;
Page/Page column 35 ;
WO 2004/062665 A1
反应条件
tin(ll) chloride in ethanol
T=70°C; 3 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/99201 A1, 2004 ;
Location in patent: Page 27 ;
WO 2004/099201 A1
反应条件
1.1: Na2S2O4; aq. NH3 / dioxane / 48 h / 25 °C
2.1: NaNO2; aq. HCl
2.2: aq. KI / cyclohexane
View Scheme
参考文献
Arvanitis, Argyrios G; Arnold, Charles R; Fitzgerald, Lawrence W; Frietze, William E; Olson, Richard E; Gilligan, Paul J; Robertson, David W
Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 289 - 291
