3-氨基-6-甲氧基-2-(三氟甲基)吡啶合成路线 （共 3 条）
反应条件
tin(ll) chloride in ethanol
T=70°C; 3 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/99201 A1, 2004 ;
Location in patent: Page 27 ;
WO 2004/099201 A1
反应条件
1: CuI; KF / dimethylformamide / 5 h / 125 - 130 °C
2: Na2S2O4; aq. NH3 / dioxane / 48 h / 25 °C
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参考文献
Arvanitis, Argyrios G; Arnold, Charles R; Fitzgerald, Lawrence W; Frietze, William E; Olson, Richard E; Gilligan, Paul J; Robertson, David W
Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 289 - 291
反应条件
1: With sulfuric acid; sodium nitrite in water
T=0 - 20°C; 2 h;
2: With potassium iodide in water
T=60°C; 3 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/99201 A1, 2004 ;
Location in patent: Page 28 ;
WO 2004/099201 A1
