1: With methanesulfonic acid; potassium iodide in 1-methyl-pyrrolidin-2-one
T=85°C; 7 h;
2: With sodium hydroxide in 1-methyl-pyrrolidin-2-one; water; ethyl acetate
参考文献
SB Pharmco Puerto Rico Inc; Neurocrine Biosciences Inc
Patent: WO2006/108693 A2, 2006 ;
Location in patent: Page/Page column 25-26 ;
WO 2006/108693 A2
