4-(三氟甲基)二苯甲酮合成路线 （共 50 条）
反应条件
dimethyl sulfoxide; triethylamine in dichloromethane T=-40 - 20°C; 8 h;
参考文献
Pandey, Sanjay K.; Bisai, Alakesh; Singh, Vinod K.
Synthetic Communications, 2007 , vol. 37, # 23 p. 4099 - 4103
反应条件
PEG200; sodium carbonate; palladium diacetate T=60°C; Suzuki reaction; 3 h;
参考文献
Xin, Bingwei; Zhang, Yuhong; Cheng, Kai
Journal of Organic Chemistry, 2006 , vol. 71, # 15 p. 5725 - 5731
反应条件
dicarbonic acid,dimethyl ester; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=80°C; 6 h;
参考文献
Yamamoto; Kakino; Narahashi; Shimizu
Bulletin of the Chemical Society of Japan, 2002 , vol. 75, # 6 p. 1333 - 1345
反应条件
1: benzoic acid With potassium phosphate in 1,4-dioxane T=20°C; 0.0833333 h; Inert atmosphere; 2: With DMEG in 1,4-dioxane T=20°C; 2 h; Inert atmosphere; 3: dihydroxy-4-(trifluoromethyl)phenylborane With tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=90°C; 16 h; Inert atmosphereSealed tube;
参考文献
Pathak, Arunendra; Rajput, Chatrasal S.; Bora, Pushkar S.; Sharma, Somesh
Tetrahedron Letters, 2013 , vol. 54, # 17 p. 2149 - 2150
反应条件
1: With 1,1'-bis-(diphenylphosphino)ferrocene; 1,10-phenanthroline; Pd(F6-acac)2; cyclohexylamine; copper(I) bromide in quinoline T=100°C; 10 h; Inert atmosphereMolecular sieve; 2: With hydrogenchloride in tetrahydrofuran; quinoline; water T=80°C; 1 h; Inert atmosphere;
参考文献
Collet, Florence; Song, Bingrui; Rudolphi, Felix; Goossen, Lukas J.
European Journal of Organic Chemistry, 2011 , # 32 p. 6486 - 6501
反应条件
PEG200; sodium carbonate; palladium diacetate T=60°C; Suzuki reaction; 3 h;
参考文献
Xin, Bingwei; Zhang, Yuhong; Cheng, Kai
Journal of Organic Chemistry, 2006 , vol. 71, # 15 p. 5725 - 5731
反应条件
Oxonereg;; potassium bromide in nitromethane T=20°C; 24 h;
参考文献
Moriyama, Katsuhiko; Takemura, Misato; Togo, Hideo
Organic Letters, 2012 , vol. 14, # 9 p. 2414 - 2417
反应条件
tris-(o-tolyl)phosphine; palladium diacetate in toluene T=20°C; 24 h;
参考文献
Yamane, Motoki; Kubota, Yuko; Narasaka, Koichi
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 2 p. 331 - 340
反应条件
hydrogenchloride; phenyl-magnesium bromide
参考文献
Pfizer Inc.
Patent: US4556676 A1, 1985 ;
US 4556676 A
反应条件
N,N,N',N,-tetramethylethylenediamine; α-n-hexadecene; palladium diacetate; di-(1-adamantyl)-n-butylphosphine in toluene T=100°C; Suzuki reaction; P=3750.38 Torr; 24 h; AutoclaveInert atmosphere;
参考文献
Neumann, Helfried; Brennfuehrer, Anne; Beller, Matthias
Chemistry - A European Journal, 2008 , vol. 14, # 12 p. 3645 - 3652
