4-(三氟甲基)二苯甲酮合成路线 （共 50 条）
反应条件
1: benzoyl chloride With indium; chloro-trimethyl-silane; ethylene dibromide; lithium chloride in 1-methyl-pyrrolidin-2-one T=40°C; 3 h; Inert atmosphere; 2: 4-trifluoromethyl-1-iodobenzene With tris-(dibenzylideneacetone)dipalladium(0) in 1-methyl-pyrrolidin-2-one T=10°C; 2 h; Inert atmosphere;
参考文献
Lee, Dohyung; Ryu, Taekyu; Park, Youngchul; Lee, Phil Ho
Organic Letters, 2014 , vol. 16, # 4 p. 1144 - 1147
反应条件
caesium carbonate; tetrakis(triphenylphosphine) palladium(0) in toluene Suzuki reaction; 0.166667 h; microwave irradiation;
参考文献
Polackova, Viera; Toma, Stefan; Augustinova, Iveta
Tetrahedron, 2006 , vol. 62, # 50 p. 11675 - 11678
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=50°C; Arylation; carbonylation; P=760 Torr; 10 h;
参考文献
Chemistry Letters, , # 2 p. 168 - 169
反应条件
oxygen; copper diacetate in dimethyl sulfoxide T=60°C; P=760.051 Torr; 16 h;
参考文献
Khan, Bilal A.; Buba, Annette E.; Goossen, Lukas J.
Chemistry - A European Journal, 2012 , vol. 18, # 6 p. 1577 - 1581
反应条件
tri-ruthenium(0)dodecacarbonyl in toluene T=140°C; 20 h;
参考文献
Tatamidani, Hiroto; Yokota, Kazuhiko; Kakiuchi, Fumitoshi; Chatani, Naoto
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5615 - 5621
反应条件
palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene] dichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride in N,N-dimethyl-formamide T=100°C; Stille carbonylative cross-coupling; 16 h;
参考文献
Lindh, Jonas; Fardost, Ashkan; Almeida, Maria; Nilsson, Peter
Tetrahedron Letters, 2010 , vol. 51, # 18 p. 2470 - 2472
反应条件
dipotassium peroxodisulfate; palladium diacetate in water; dimethyl sulfoxide T=20°C; 3 h;
参考文献
Li, Mingzong; Wang, Cong; Ge, Haibo
Organic Letters, 2011 , vol. 13, # 8 p. 2062 - 2064
反应条件
anhydrous iron chloride; potassium acetate; sodium hydrogencarbonate; iron(II) chloride T=100°C; Suzuki Coupling; P=760.051 Torr; 12 h; Schlenk technique;
参考文献
Zhong, Yanzhen; Han, Wei
Chemical Communications, 2014 , vol. 50, # 29 p. 3874 - 3877
反应条件
palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene] dichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride in N,N-dimethyl-formamide T=100°C; Stille carbonylative cross-coupling; 16 h;
参考文献
Lindh, Jonas; Fardost, Ashkan; Almeida, Maria; Nilsson, Peter
Tetrahedron Letters, 2010 , vol. 51, # 18 p. 2470 - 2472
反应条件
potassium fluoride; 18-crown-6 ether; 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; potassium tert-butylate in tetrahydrofuran T=25°C; 4 h; Inert atmosphere;
参考文献
Biju, Akkattu T.; Glorius, Frank
Angewandte Chemie - International Edition, 2010 , vol. 49, # 50 p. 9761 - 9764
