4-(三氟甲基)二苯甲酮合成路线 （共 50 条）
反应条件
1: (4-Amino-phenyl)phenyl-methanone With hydrogenchloride in water T=0°C; 0.0833333 h; Inert atmosphereSchlenk technique; 2: With tert.-butylnitrite T=0°C; 0.25 h; Inert atmosphereSchlenk technique; 3: trifluoromethylsilver T=-78 - 20°C; 4 h; Inert atmosphereSchlenk technique;
参考文献
Wang, Xi; Xu, Yan; Mo, Fanyang; Ji, Guojing; Qiu, Di; Feng, Jiajie; Ye, Yuxuan; Zhang, Songnan; Zhang, Yan; Wang, Jianbo
Journal of the American Chemical Society, 2013 , vol. 135, # 28 p. 10330 - 10333
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran Negishi-type cross-coupling; Heating;
参考文献
Wang, Donghui; Zhang, Zhaoguo
Organic Letters, 2003 , vol. 5, # 24 p. 4645 - 4648
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1-methyl-pyrrolidin-2-one T=60°C; 6 h;
参考文献
Journal of Organometallic Chemistry, , vol. 693, # 17 p. 2949 - 2953
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1-methyl-pyrrolidin-2-one T=60°C; 6 h;
参考文献
Journal of Organometallic Chemistry, , vol. 693, # 17 p. 2949 - 2953
反应条件
potassium phosphate; PdCl(NH2C6H4C6H4)(C6H4(CH3)4O3PC6H5); water in 2-methyl tetrahydrofuran T=60°C; 44 h; Inert atmosphere;
参考文献
Schmink, Jason R.; Krska, Shane W.
Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19574 - 19577
反应条件
1: RhCl(COD)*P(n-Pr)3; K2CO3 / bis-(2-methoxy-ethyl) ether / 146 h / 160 °C 2: 6 N aq. HCl / 16 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 122, # 48 p. 12043 - 12044
反应条件
1: RhCl(COD)*P(n-Pr)3; K2CO3 / bis-(2-methoxy-ethyl) ether / 50 h / 160 °C 2: 6 N aq. HCl / 16 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 122, # 48 p. 12043 - 12044
反应条件
in tetrahydrofuran T=-78 - 0°C; 1 h; Inert atmosphere;
参考文献
Akhbar, Ahmed R.; Chudasama, Vijay; Fitzmaurice, Richard J.; Powell, Lyn; Caddick, Stephen
Chemical Communications, 2014 , vol. 50, # 6 p. 743 - 746
反应条件
1: With silver trifluoromethanesulfonate; (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl in toluene T=-50°C; 40 h; Inert atmosphere; 2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in benzene T=20°C; optical yield given as percent eestereospecific reaction;
参考文献
Organic Letters, , vol. 10, # 5 p. 993 - 996
反应条件
aluminium trichloride in dichloromethane T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 2 p. 347 - 350
