2-羟甲基-3,4-二甲氧基吡啶合成路线 （共 15 条）
反应条件
1: With acetic anhydride T=90°C; 2 h; 2: With sodium hydroxide in water T=80°C; 2 h;
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
sodium hydroxide T=80°C; 2 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
参考文献
US4145546 A1, ;
US 4145546 A
反应条件
1: 85 percent / POCl3 / 10 h / Heating 2: NaOMe / 10 h / Heating 3: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 4: 4 h / 100 °C 5: 2 M NaOH / 1 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: NaOMe / 10 h / Heating 2: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 3: 4 h / 100 °C 4: 2 M NaOH / 1 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 68 percent / K2CO3 / acetone / 19 h / Heating 2: 77 percent / conc. ammonia / 3 h / 110 °C 3: 85 percent / POCl3 / 10 h / Heating 4: NaOMe / 10 h / Heating 5: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 6: 4 h / 100 °C 7: 2 M NaOH / 1 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 77 percent / conc. ammonia / 3 h / 110 °C 2: 85 percent / POCl3 / 10 h / Heating 3: NaOMe / 10 h / Heating 4: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 5: 4 h / 100 °C 6: 2 M NaOH / 1 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 2: 4 h / 100 °C 3: 2 M NaOH / 1 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 58 percent / 98percent HNO3 / acetic acid / 33 h / 80 °C 2: 88 percent / NaOMe / 16 h / 40 °C 3: 2 h / 90 °C 4: 2 N aq. NaOH / 2 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 91 percent / NaOMe / 18 h 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
