2-(氯甲基)-3,4-二甲氧基吡啶盐酸盐合成路线 （共 17 条）
反应条件
thionyl chloride in dichloromethane 2 h;
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 4 h / 100 °C 2: 2 M NaOH / 1 h / 100 °C 3: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 85 percent / POCl3 / 10 h / Heating 2: NaOMe / 10 h / Heating 3: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 4: 4 h / 100 °C 5: 2 M NaOH / 1 h / 100 °C 6: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: NaOMe / 10 h / Heating 2: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 3: 4 h / 100 °C 4: 2 M NaOH / 1 h / 100 °C 5: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 2 M NaOH / 1 h / 100 °C 2: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 91 percent / NaOMe / 18 h 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C 4: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 68 percent / K2CO3 / acetone / 19 h / Heating 2: 77 percent / conc. ammonia / 3 h / 110 °C 3: 85 percent / POCl3 / 10 h / Heating 4: NaOMe / 10 h / Heating 5: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 6: 4 h / 100 °C 7: 2 M NaOH / 1 h / 100 °C 8: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 77 percent / conc. ammonia / 3 h / 110 °C 2: 85 percent / POCl3 / 10 h / Heating 3: NaOMe / 10 h / Heating 4: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 5: 4 h / 100 °C 6: 2 M NaOH / 1 h / 100 °C 7: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 2: 4 h / 100 °C 3: 2 M NaOH / 1 h / 100 °C 4: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 88 percent / NaOMe / 16 h / 40 °C 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C 4: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
