2-(氯甲基)-3,4-二甲氧基吡啶盐酸盐合成路线 （共 17 条）
反应条件
1: 58 percent / 98percent HNO3 / acetic acid / 33 h / 80 °C 2: 88 percent / NaOMe / 16 h / 40 °C 3: 2 h / 90 °C 4: 2 N aq. NaOH / 2 h / 80 °C 5: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
反应条件
1.1: sodium bicarbonate / CHCl3 1.2: 84 percent / m-chloroperbenzoic acid / 2.42 h / 5 °C 2.1: 98.44 percent / potassium carbonate / dimethylformamide / 20 °C View Scheme
参考文献
Ray, Purna C.; Mittapelli, Vasantha; Rohatgi, Amit; Tyagi, Om Dutt
Synthetic Communications, 2007 , vol. 37, # 17 p. 2861 - 2868
反应条件
sodium hydroxide in water T=25 - 30°C; 4 - 5 h;
参考文献
DR. REDDY'S LABORTORIES, LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/45777 A2, 2008 ;
Location in patent: Page/Page column 25-26 ;
反应条件
1: 5-difluoromethoxy-2-mercapto-1H-benzimidazole With sodium hydroxide in water; acetone T=20 - 25°C; 0.5 h; 2: 3,4-dimethoxy-2-chloromethylpyridine hydrochloride in water; acetone T=23 - 25°C; 1 h;
参考文献
UNICHEM LABORATORIES LIMITED
Patent: WO2007/86077 A2, 2007 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: 2 N aq. NaOH / ethanol / 2 h / 50 °C 2: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: With sodium hydroxide; tetrabutylammomium bromide in dichloromethane; water T=25 - 30°C; 12 h; 2: With sodium hydroxide; sodium hypochlorite in dichloromethane; water T=0 - 8°C; 6 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED; WAIN, Christopher, Paul
Patent: WO2006/64249 A2, 2006 ;
Location in patent: Page/Page column 8; 10 ;
反应条件
1: With sodium hydrogencarbonate in chloroform
2: With 3-chloro-benzenecarboperoxoic acid
T=5°C; 2.41667 h; Further stages.;
参考文献
Ray, Purna C.; Mittapelli, Vasantha; Rohatgi, Amit; Tyagi, Om Dutt
Synthetic Communications, 2007 , vol. 37, # 17 p. 2861 - 2868
