2-氯-4-三氟甲基-1,3-噻唑-5-羧酸乙酯合成路线 （共 9 条）
反应条件
copper dichloride in acetonitrile T=20 - 50°C;
参考文献
ELI LILLY AND COMPANY; BASTIAN, Jolie, Anne; CLAY, Julia, Marie; COHEN, Jeffrey, Daniel; HIPSKIND, Philip, Arthur; LOBB, Karen, Lynn; SALL, Daniel, Jon; WILSON (NEE TAKAKUWA), Takako; THOMPSON, Michelle, Lee
Patent: WO2010/56588 A1, 2010 ;
Location in patent: Page/Page column 13 ;
反应条件
trichlorophosphate in N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chlorobenzene; Petroleum ether
反应条件
trichlorophosphate Heating;
参考文献
Liu, Chang-Ling; Li, Miao; Chi, Hui-Wei; Hou, Chun-Qing; Li, Zheng-Ming
Journal of Fluorine Chemistry, 2006 , vol. 127, # 6 p. 796 - 799
反应条件
1: 55 percent / chlorobenzene / 2 h / 135 °C 2: 92 percent / POCl3 / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 1621 - 1630
反应条件
sodium tetrahydroborate in N,N-dimethyl-formamide T=0°C; 0.333333 h; exothermic reaction;
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
sodium hydroxide in tetrahydrofuran 16 h; Ambient temperature;
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
1: 73 percent / aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature 2: 98 percent / SOCl2 / 6 h / Heating 3: 53 percent / 6 h / 130 - 140 °C View Scheme
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
in dimethyl sulfoxide T=20°C;
参考文献
ELI LILLY AND COMPANY; BASTIAN, Jolie, Anne; CLAY, Julia, Marie; COHEN, Jeffrey, Daniel; HIPSKIND, Philip, Arthur; LOBB, Karen, Lynn; SALL, Daniel, Jon; WILSON (NEE TAKAKUWA), Takako; THOMPSON, Michelle, Lee
Patent: WO2010/56588 A1, 2010 ;
Location in patent: Page/Page column 13 ;
反应条件
1: 73 percent / aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature
2: 98 percent / SOCl2 / 6 h / Heating
3: 95 percent / 6 h / Heating
View Scheme
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
