2-氨基-4-异丙基噻唑-5-羧酸乙酯合成路线 （共 6 条）
反应条件
1: 4-methyl-3-oxo-pentanoic acid ethyl ester With thionyl chloride in dichloromethane
T=0 - 20°C; 1 h;
2: thiourea in 1,4-dioxane; water
T=80°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 18 ;
反应条件
in ethanol
T=23 - 100°C; 1 h;
参考文献
GRÜNENTHAL GMBH; LUCAS, Simon; Kühnert, Sven; Bahrenberg, Gregor; Schröder, Wolfgang
Patent: US2014/148454 A1, 2014 ;
Location in patent: Paragraph 0716 ;
反应条件
N-bromosuccinmide; xanthan sulfuric acid
T=20°C; 0.3 h;
参考文献
Kuarm, Bowroju S.; Madhav, Janganati V.; Rajitha, Bhargavi
Letters in Organic Chemistry, 2011 , vol. 8, # 8 p. 549 - 553
参考文献
Monsanto Company
Patent: US4308391 A1, 1981 ;
反应条件
in ethanol
16 h; Heating;
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
copper(I) bromide; isopentyl nitrite in acetonitrile
T=80°C; 3 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 18-19 ;
