2-溴-4-三氟甲基噻唑-5-甲酸乙酯合成路线 （共 4 条）
反应条件
1: With sodium nitrite in water; hydrogen bromide T=0°C; 2: With copper bromide in water; hydrogen bromide T=0 - 20°C; 2.5 h;
参考文献
Boy, Kenneth M.; Wu, Yong-Jin; Guernon, Jason M.
Patent: US2004/147401 A1, 2004 ;
Location in patent: Page 32 ;
US 20040147401 A1
反应条件
1.1: 75 percent / ethanol / 3 h / Heating 2.1: sodium nitrite / aq. HBr; H2O / 0 °C 2.2: 93 percent / copper bromide / aq. HBr; H2O / 2.5 h / 0 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 13 p. 2251 - 2252
反应条件
2: 72 percent / ethanol / 16 h / Heating 3: 1.) 85percentH3PO4, 70percent HNO3, aq. NaNO2, 2.) aq. HBr, CuBr; / 1.) -10 to -5 deg C, 10 min; View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 1621 - 1630
反应条件
tetrakis(triphenylphosphine) palladium(0); 2,6-di-tert-butyl-4-methyl-phenol in toluene
T=120°C; 0.416667 h;
参考文献
Boy, Kenneth M.; Wu, Yong-Jin
Patent: US2004/138268 A1, 2004 ;
Location in patent: Page/Page column 15-16 ;
US 20040138268 A1
