2-甲氧基-4-(甲硫基)苯甲酸合成路线 （共 17 条）
反应条件
1: 70 percent / POCl3 / 1.) RT, 0.5 h, 2.) reflux, 6 h 2: m-chloroperbenzoic acid / CHCl3 / 1.5 h / -15 °C 3: 43 percent / H2 / 10percent Pd/C / ethanol / 760 Torr View Scheme
参考文献
Barraclough; Black; Cambridge; Collard; Firmin; Gerskowitch; Glen; Giles; Hill; Hull; Iyer; King; Kneen; Lindon; Nobbs; Randall; Shah; Smith; Vine; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2231 - 2239
反应条件
sodium hydroxide in methanol
Heating; Yield given;
参考文献
Robertson; Beedle; Krushinski; Pollock; Wilson; Wyss; Hayes
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 717 - 727
反应条件
1: NaNO2, HCl / H2O / 0.5 h / 0 - 5 °C
2: 41 percent / Cu / 1.) from 0 deg C to 20 deg C, 3 h, 2.) RT, overnight
View Scheme
参考文献
Barraclough, P.; Beams, R. M.; Black, J. W.; Cambridge, D.; Collard, D.; et al.
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 6 p. 467 - 477
反应条件
1: 87 percent / 10percent NaOH / 3 h / Heating
2: NaNO2, HCl / H2O / 0.5 h / 0 - 5 °C
3: 41 percent / Cu / 1.) from 0 deg C to 20 deg C, 3 h, 2.) RT, overnight
View Scheme
参考文献
Barraclough, P.; Beams, R. M.; Black, J. W.; Cambridge, D.; Collard, D.; et al.
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 6 p. 467 - 477
反应条件
copper
1.) from 0 deg C to 20 deg C, 3 h, 2.) RT, overnight;
参考文献
Barraclough, P.; Beams, R. M.; Black, J. W.; Cambridge, D.; Collard, D.; et al.
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 6 p. 467 - 477
反应条件
1: SOCl2
2: NEt3, DMAP / dimethylformamide
3: 1.) NaH / 1.) DMF
4: DOWEX 50X2 / methanol
5: 1.) NaH / 1.) DMF
6: aq. NaOH / 235 °C
7: 1.) NaH / 1.) DMF
View Scheme
参考文献
Patek; Lebl
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3891 - 3894
反应条件
1: NEt3, DMAP / dimethylformamide
2: 1.) NaH / 1.) DMF
3: DOWEX 50X2 / methanol
4: 1.) NaH / 1.) DMF
5: aq. NaOH / 235 °C
6: 1.) NaH / 1.) DMF
View Scheme
参考文献
Patek; Lebl
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3891 - 3894
反应条件
1: 1.) NaH / 1.) DMF
2: DOWEX 50X2 / methanol
3: 1.) NaH / 1.) DMF
4: aq. NaOH / 235 °C
5: 1.) NaH / 1.) DMF
View Scheme
参考文献
Patek; Lebl
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3891 - 3894
反应条件
triethylamine in acetone
2 h; Ambient temperature;
参考文献
Komeshima; Osawa; Nishitoba; Jinno; Kiriu
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 2 p. 351 - 356
参考文献
Shah; Bhatt; Kanga
Journal of the Chemical Society, 1933 , p. 1375,1379
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1934 , vol. 3/2, p. 155
