2-甲氧基-4-(甲硫基)苯甲酸合成路线 （共 17 条）
反应条件
1: 1.) NaH / 1.) DMF
2: aq. NaOH / 235 °C
3: 1.) NaH / 1.) DMF
View Scheme
参考文献
Patek; Lebl
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3891 - 3894
反应条件
1: aq. NaOH / 235 °C
2: 1.) NaH / 1.) DMF
View Scheme
参考文献
Patek; Lebl
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3891 - 3894
反应条件
1: tin; aqueous hydrochloric acid
2: aq. NaOH solution
View Scheme
参考文献
Shah; Bhatt; Kanga
Journal of the Chemical Society, 1933 , p. 1375,1379
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1934 , vol. 3/2, p. 155
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine
also without TMEDA; Product distribution;
参考文献
Cabiddu, Salvatore; Maccioni, Antonio; Piras, Pier Paolo; Plumitallo, Antonio
Gazzetta Chimica Italiana, 1981 , vol. 111, # 3/4 p. 123 - 128
反应条件
1: SOCl2 / benzene / 1.) RT, overnight, 2.) reflux, 1 h
2: pyridine / 72 h / Ambient temperature
3: 55 percent / POCl3 / pyridine / 3 h / 0 - 20 °C
4: 76 percent / m-chloroperbenzoic acid / CHCl3 / 1.5 h / -15 °C
View Scheme
参考文献
Barraclough; Black; Cambridge; Collard; Firmin; Gerskowitch; Glen; Giles; Hill; Hull; Iyer; King; Kneen; Lindon; Nobbs; Randall; Shah; Smith; Vine; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2231 - 2239
反应条件
boron tribromide in dichloromethane
T=-65°C; 3 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/108677 A1, 2004 ;
Location in patent: Page 38-39 ;
WO 2004/108677 A1
反应条件
1: thionyl chloride / 2 h / Heating
2: 80 percent / triethylamine / toluene / Heating
View Scheme
参考文献
Jonas; Wurziger
Tetrahedron, 1987 , vol. 43, # 20 p. 4539-4547
