反应条件
1: 40 percent / benzyltrimethylammonium chloride / CH2Cl2; H2O
2: 50 percent / KH / 2-methyl-propan-2-ol / 1.5 h / Ambient temperature
3: 68 percent / dimethylformamide / 4 h / Heating
4: 1.) NaH, 2.) K2CO3 / 1.) DMF, RT, 0.5 h, 2.) DMF, a) overnight, b) reflux, 1.5 h
View Scheme
参考文献
Lantos, I.; Bender, P. E.; Razgaitis, K. A.; Sutton, B. M.; DiMartino, M. J.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 72 - 75