6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑合成路线 （共 5 条）
反应条件
sulfur in 1,3,5-trimethyl-benzene
2 h; Heating;
参考文献
Lantos, Ivan; Gombatz, Kerry; McGuire, Michael; Pridgen, Lendon; Remich, James; Shilcrat, Susan
Journal of Organic Chemistry, 1988 , vol. 53, # 18 p. 4223 - 4227
反应条件
1: 40 percent / dimethylformamide / 4 h / Heating
2: 1.) NaH, 2.) K2CO3 / 1.) DMF, RT, 0.5 h, 2.) DMF, a) overnight, b) reflux, 1.5 h
View Scheme
参考文献
Lantos, I.; Bender, P. E.; Razgaitis, K. A.; Sutton, B. M.; DiMartino, M. J.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 72 - 75
反应条件
1: 86 percent / CH2Cl2 / 0 - 20 °C
2: 92 percent / S / 1,3,5-trimethyl-benzene / 2 h / Heating
View Scheme
参考文献
Lantos, Ivan; Gombatz, Kerry; McGuire, Michael; Pridgen, Lendon; Remich, James; Shilcrat, Susan
Journal of Organic Chemistry, 1988 , vol. 53, # 18 p. 4223 - 4227
反应条件
sodium hydride; potassium carbonate
1.) DMF, RT, 0.5 h, 2.) DMF, a) overnight, b) reflux, 1.5 h; Multistep reaction;
参考文献
Lantos, I.; Bender, P. E.; Razgaitis, K. A.; Sutton, B. M.; DiMartino, M. J.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 72 - 75
反应条件
sodium carbonate; magnesium sulfate; 3-chloro-benzenecarboperoxoic acid in dichloromethane
参考文献
SmithKline Corporation
Patent: US4175127 A1, 1979 ;
