反应条件
1: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) RT, overnight
2: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 0.5 h, 2.) from -70 deg C to RT, 2 h
3: 95 percent / CH3ONa / methanol / 24 h / Ambient temperature
4: 80 percent / CrO3, pyridine / CH2Cl2 / 1 h / 14 - 25 °C
5: 42 percent / K2CO3, 18-crown-6 / benzene / 0.67 h / 56 °C
6: 97 percent / NaBH4, CeCl3*7H2O / methanol / 0.17 h / 0 - 5 °C
7: 100 percent / Et3N / CH2Cl2 / 0.17 h / -5 - 0 °C
8: 74 percent / LiN3, P(NMe2)3 / dimethylsulfoxide / Ambient temperature
9: H2 / Lindlar's catalyst / butan-1-ol / 3 h / 760 Torr
10: Et3N / butan-1-ol / 20 h / Heating
11: conc. HCl / 42 h / Ambient temperature
12: 70 percent / liquid NH3 / methanol / 18 h / 60 °C
13: 50 percent / 1 M BCl3 / CH2Cl2; hexane / 2.5 h / -75 °C
View Scheme
参考文献
Marquez, Victor E.; Lim, Mu-Ill; Tseng, Christopher K.-H.; Markovac, Anica; Priest, Matthew A.; et al.
Journal of Organic Chemistry, 1988 , vol. 53, # 24 p. 5709 - 5714
