反应条件
2: CaCO3 / toluene / 15 h / Heating
3: 82 percent / DIBAH / CH2Cl2 / 4 h / -78 °C
4: 100 percent / triethylamine / CH2Cl2 / 0.75 h / 5 °C
5: 1) NaH, 18-crown-6 / 1) DMF, 60 deg C, 6 h, 2) DMF, 48 h, RT, then 65 deg C, 6 h
6: 72 percent / CF3COOH, H2O / 50 °C
View Scheme
参考文献
Wolfe, Michael S.; Anderson, Blake L.; Borcherding, David R.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4712 - 4717
