O,O′-二(三甲基甲硅烷基)胸苷合成路线 （共 89 条）
反应条件
trimethylsilyl trifluoromethanesulfonate in dichloromethane T=-20°C; 0.5 h; β-stereoselectivity; further substituted Bz protecting group at C-3; Product distribution;
参考文献
Iimori, Takamasa; Kobayashi, Hiroshi; Hashimoto, Shun-Ichi; Ikegami, Shiro
Heterocycles, 1996 , vol. 42, # 2 p. 485 - 488
反应条件
chloro-trimethyl-silane; 4 A molecular sieve; potassium iodide in acetonitrile 3 h;
参考文献
Recueil: Journal of the Royal Netherlands Chemical Society, , vol. 103, # 6 p. 192 - 196
反应条件
1.) acetonitrile, 0 degC, 2.) 0 degC to R.T. 2 h; Yield given. Multistep reaction;
参考文献
Robins; Hatfield
Canadian Journal of Chemistry, 1982 , vol. 60, # 5 p. 547 - 553
反应条件
1: 39 percent / CF3SO2-OSiMe3 / acetonitrile / 2 h / -30 °C 2: 89 percent / 33percent MeNH2 / ethanol / 2.5 h / Heating View Scheme
参考文献
Motawia; Wengel; Abdel-Megid; Pedersen
Synthesis, 1989 , # 5 p. 384 - 387
反应条件
1: tert-butyldimethylsilyl triflate / acetonitrile / 1.5 h / Ambient temperature 2: 33 percent / 50percent aq. trifluoroacetic acid / 20 h / Ambient temperature View Scheme
参考文献
Sugimura; Osumi; Yamazaki; Yamaya
Tetrahedron Letters, 1991 , vol. 32, # 15 p. 1813 - 1816
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile T=-30 - 20°C; Further byproducts given;
参考文献
Tetrahedron, , vol. 57, # 35 p. 7513 - 7517
反应条件
1: 83 percent / NBS, mol. sieves 4A / CH2Cl2 / -78 °C 2: Dowex R 50W, H(1+) form / methanol View Scheme
参考文献
Sujino, Keiko; Yoshida, Tomoyasu; Sugimura, Hideyuki
Tetrahedron Letters, 1996 , vol. 37, # 34 p. 6133 - 6136
反应条件
1: TMSOTf / acetonitrile / 25 °C 2: 85 percent / NaOMe / methanol View Scheme
参考文献
Sugimura; Osumi; Yamazaki; Yamaya
Tetrahedron Letters, 1991 , vol. 32, # 15 p. 1813 - 1816
反应条件
chloro-trimethyl-silane; 4 A molecular sieve; potassium iodide in acetonitrile 3 h;
参考文献
Recueil: Journal of the Royal Netherlands Chemical Society, , vol. 103, # 6 p. 192 - 196
反应条件
1: 93 percent / SnCl4 / 1,2-dichloro-ethane / 48 h / 20 °C 2: 80 percent / 1 N sodium methylate / methanol / 3 h / 20 °C 3: 1.) acetylsalicylic chloroanhydride, 2.) 0.5 N HCl / 1.) nitromethane, 20 deg C, 15 h, 2.) water, dioxane, 100 deg C, 2.5 h View Scheme
参考文献
Kvasyuk, E. I.; Kulak, T. I.; Tkachenko, O. V.; Mikhaylopulo, I. A.; Zinchenko, A. I.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 6 p. 493 - 496
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 6 p. 699 - 702
