O,O′-二(三甲基甲硅烷基)胸苷合成路线 （共 89 条）
反应条件
1: 1,2-dichloro-ethane / 1 h / 100 °C 2: sodium methoxide / methanol / 0.08 h / Heating View Scheme
参考文献
Howell, Henry G.; Brodfuehrer, Paul R.; Brundidge, Steven P.; Benigni, Daniel A.; Sapino, Chester
Journal of Organic Chemistry, 1988 , vol. 53, p. 85 - 88
反应条件
chloro-trimethyl-silane; potassium iodide in acetonitrile 16 h; Ambient temperature; Yield given;
参考文献
Eriksson, Andre H.; Elm, Peter L.; Begtrup, Mikael; Brodin, Birger; Nielsen, Robert; Steffansen, Bente
European Journal of Pharmaceutical Sciences, 2005 , vol. 25, # 1 p. 145 - 154
反应条件
1: 1.) acetonitrile, 0 degC, 2.) 0 degC to R.T. 2 h 2: 93 percent / Na / methanol / 2 h / Ambient temperature View Scheme
参考文献
Robins; Hatfield
Canadian Journal of Chemistry, 1982 , vol. 60, # 5 p. 547 - 553
反应条件
1: 42 percent / SnCl4 / 1,2-dichloro-ethane / Ambient temperature 2: 1) NH4OH, 2) NaN3 / 1) MeOH, r.t., 2) DMF, 100 deg C View Scheme
参考文献
Murata; Achiwa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 3 p. 836 - 838
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile 1) 1.5h, -30 deg C 2) 2.5h, r.t.;
参考文献
Motawia, Mohammed S.; Pedersen, Erik B.
Liebigs Annalen der Chemie, 1990 , # 11 p. 1137 - 1139
反应条件
1: 55 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.5 h / Ambient temperature 2: phosphorus oxychloride, pyridine / 1 h 3: pyridine / 24 h / Ambient temperature 4: 1.) NaH, 3.) MeOH View Scheme
参考文献
Ross; Springer; Vasquez; Andrews; Cook; Acevedo
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 765 - 769
反应条件
1: 10 percent / 240 h / 20 °C 2: 80 percent / azidotrimethylsilane; tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 65 °C 3: 90 percent / hydrogen / Pd/C / methanol / 2.5 h View Scheme
参考文献
Nawrot; Michalak; Olejniczak; Wieczorek; Lis; Stec
Tetrahedron, 2001 , vol. 57, # 18 p. 3979 - 3985
反应条件
silver trifluoroacetate in solid 48 h; Ambient temperature;
参考文献
Im, Juwon; Kim, Jaechul; Kim, Sukjin; Hahn, Bosup; Toda, Fumio
Tetrahedron Letters, 1997 , vol. 38, # 3 p. 451 - 452
反应条件
silver trifluoroacetate in solid 48 h; Ambient temperature;
参考文献
Im, Juwon; Kim, Jaechul; Kim, Sukjin; Hahn, Bosup; Toda, Fumio
Tetrahedron Letters, 1997 , vol. 38, # 3 p. 451 - 452
反应条件
2.) hydrolyse; Yield given. Multistep reaction;
参考文献
Semenov; Akamsin; Reznik
Russian Journal of General Chemistry, 2007 , vol. 77, # 8 p. 1430 - 1440
