O,O′-二(三甲基甲硅烷基)胸苷合成路线 （共 89 条）
反应条件
1: 90 percent / TMSOTf / acetonitrile / -20 - 0 °C 2: 94 percent / TMSOTf / acetonitrile / -20 - 20 °C 3: 94 percent / H2 / Rh/Al2O3 / methanol / 750.08 Torr 4: pig liver esterase; aq. NaOH / aq. phosphate buffer / pH 7.4 5: 91 percent / sodium borohydride / H2O / 0 - 20 °C View Scheme
参考文献
Albert, Martin; De Souza, Dominic; Feiertag, Petra; Hoenig, Helmut
Organic letters, 2002 , vol. 4, # 19 p. 3251 - 3254
反应条件
1: 91 percent / SnCl4 / 1,2-dichloro-ethane / 2 h / 20 °C 2: 98 percent / ammonia / methanol / 96 h View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 8 p. 1249 - 1263
反应条件
in tetrahydrofuran 144 h; Inert atmosphereReflux;
参考文献
Kociok-Koehn, Gabriele; Mahon, Mary F.; Molloy, Kieran C.; Price, Gareth J.; Prior, Timothy J.; Smith, Douglas R. G.
Dalton Transactions, 2014 , vol. 43, # 21 p. 7734 - 7746
反应条件
1: 176 mg / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.5 h / -15 °C 2: 85 percent / methylamine / ethanol / 20 °C View Scheme
参考文献
Lau; Pedersen; Nielsen
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1991 , vol. 45, # 6 p. 616 - 620
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile T=-40 - -30°C; 1 h;
参考文献
Lau; Pedersen; Jensen; Nielsen
Archiv der Pharmazie, 1991 , vol. 324, # 2 p. 83 - 89
反应条件
1: NaI / 1,2-dichloro-ethane / 3 h / Heating 2: 1.) LDA / 1) THF, below -70 deg C, 1.5 h; 2) THF, below -70 deg C, 30 min View Scheme
参考文献
Negron; Jacobo Molina; Islas; Cruz-Almanza
Synthetic Communications, 1999 , vol. 29, # 3 p. 435 - 445
反应条件
in 1,2-dichloro-ethane 48 h; Heating; Yield given;
参考文献
Gonzalez-Diaz, Humberto; Bonet, Isis; Teran, Carmen; De Clercq, Erik; Bello, Rafael; Garcia, Maria M.; Santana, Lourdes; Uriarte, Eugenio
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 5 p. 580 - 585
反应条件
1: trimethylsilyl triflate / acetonitrile / 24.5 h / -40 - 20 °C 2: ammonia / methanol / 16 h / Ambient temperature View Scheme
参考文献
Schmidt; Pedersen; Nielsen
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1994 , vol. 48, # 3 p. 215 - 221
反应条件
1: SnCl4 2: NaHCO3 / H2O 3: 98 percent / Et3N; POCl3 / acetonitrile 4: NH3 / dioxane / 24 h / 20 °C 5: NH3 / methanol View Scheme
参考文献
Abdel Rahman, Adel A.-H.; Wada, Takeshi; Saigo, Kazuhiko
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1061 - 1063
反应条件
1: 95 percent / SnCl4 / acetonitrile / 18 h 2: 90 percent / NH3 / methanol / 72 h / 0 °C View Scheme
参考文献
Sivets, Grigorii G.; Klennitskaya, Tatjana V.; Zhernosek, Elena V.; Mikhailopulo, Igor A.
Synthesis, 2002 , # 2 p. 253 - 259
