O,O′-二(三甲基甲硅烷基)胸苷合成路线 （共 89 条）
反应条件
ammonium sulfate
T=130°C; 15 h;
参考文献
Tronchet; Iznaden; Barbalet-Rey; Dhimane; Ricca; Balzarini; De Clercq
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 5 p. 555 - 560
参考文献
Johnson; Pillai; Grollman; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 954 - 958
反应条件
in 1,2-dichloro-ethane
T=65 - 70°C;
参考文献
Almond; Lowen; Martin; Rideout
Nucleosides and Nucleotides, 1993 , vol. 12, # 9 p. 905 - 913
反应条件
in acetonitrile
T=70°C; 0.25 h;
参考文献
Hyrosova; Fisera; Jame; Pronayova; Medvecky; Koos
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 1 p. 10 - 17
参考文献
Haraguchi, Kazuhiro; Shiina, Noriaki; Yoshimura, Yuichi; Shimada, Hisashi; Hashimoto, Kyoko; Tanaka, Hiromichi
Organic Letters, 2004 , vol. 6, # 16 p. 2645 - 2648
反应条件
1: 40 percent / tin tetrachloride / acetonitrile / 20 h / 20 °C
2: 71 percent / hydrogen chloride / methanol / 3 h / 20 °C
3: mesyl chloride; pyridine
4: Dowex 50 OH(1-) form / methanol
5: 99 percent / pyridine / 20 °C
View Scheme
参考文献
Rejman, Dominik; Masojidkova, Milena; Rosenberg, Ivan
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 11 p. 1683 - 1705
反应条件
1: 73 percent / SnCl4 / acetonitrile / 4 h / Ambient temperature
2: 70 percent / 1 M aq. H2SO4 / acetonitrile / 18 h / 75 °C
3: 76.2 percent / pyridine / 24 h
4: 30 percent / NaI / 1,2-dimethoxy-ethane / 38 h / Heating
View Scheme
参考文献
Tolstikov, G. A.; Mustafin, A. G.; Gataullin, R. R.; Abdrakhmanov, I. B.; Plyasunova, A. G.; Pokrovskii, A. G.
Chemistry of Natural Compounds, 1993 , vol. 29, # 1 p. 113 - 115
Khimiya Prirodnykh Soedinenii, 1993 , # 1 p. 133 - 136
反应条件
1: 1.) CF3SO3SiMe3, 2.) NaOMe, MeOH / 1.) 1,2-dichloroethane, 15 min, reflux, 2.) 1,2-dichloroethane, 20 deg C, 1 h
2: 95 percent / pyridine / 0.17 h / Heating
3: 1.) SOCl2, 2.) NH3, methanol / 1.) reflux, 2 min, 2.) 20 deg C, 24 h
View Scheme
参考文献
Fedorov; Kazmina; Novicov; Gurskaya; Bochkarev; Jasko; Victorova; Kukhanova; Balzarini; De Clercq; Krayevsky
Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4567 - 4575
反应条件
1: 66 percent / SnCl4 / 1,2-dichloro-ethane / Ambient temperature; overnight
2: 86 percent / conc. HCl / dioxane / 48 h / Ambient temperature
3: 96 percent / pyridine / 4 h / Ambient temperature
4: 95 percent / DBU / acetonitrile / Ambient temperature; overnight
5: 91 percent / HCl / dimethylformamide / 0.75 h / 100 °C
6: 95 percent / Bu3SnH, 2,2'-azobis(2-methylpropiononitrile) / toluene / 0.75 h / 100 °C
7: 83 percent / NaOMe / methanol / Ambient temperature; overnight
8: conc. H2SO4 / acetone; dimethylformamide / 0.5 h
9: 91 percent / pyridine / 4 h / Ambient temperature
10: 82 percent / LiN3 / dimethylformamide / 5 h / 100 °C
11: 94 percent / Dowex 50(H+), 80percent aq. MeOH / 0.67 h / Heating
View Scheme
参考文献
Hrebabecky; Holy
Carbohydrate Research, 1991 , vol. 216, p. 179 - 186
反应条件
1: 36 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 4 h / Heating
2: 22 percent / NH3 / methanol / 15 h / 23 °C
View Scheme
参考文献
Dyson; Coe; Walker
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2782 - 2786
