O,O′-二(三甲基甲硅烷基)胸苷合成路线 （共 89 条）
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile
T=-35°C; 0.25 h;
参考文献
Lau; Pedersen; Nielsen
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1991 , vol. 45, # 6 p. 616 - 620
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile
T=-15°C; 0.5 h;
参考文献
Lau; Pedersen; Nielsen
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1991 , vol. 45, # 6 p. 616 - 620
反应条件
1: N-iodosuccinimide / acetonitrile / 4 h
2: 88 percent / BCl3 / CH2Cl2 / 4 h / -78 °C
View Scheme
参考文献
Uenishi, Jun'ichi; Takahashi, Keiji; Motoyama, Mitsuhiro; Akashi, Haruo
Chemistry Letters, 1993 , # 2 p. 255 - 256
反应条件
1: acetonitrile / 0.5 h / Heating
2: 90 percent / NaOMe / methanol / 24 h / Ambient temperature
3: 71 percent / pyridine / 1.25 h / Ambient temperature
4: 65 percent / tetrabutylammonium hydroxide, pyridine / acetonitrile / 48 h / Heating
5: 1.) NaH / 1.) DMF, -40 deg C, 0.75 h, 2.) DMF, a) from -40 to -30 deg C, 0.75 h, b) RT, 4 h
6: 71 percent / potassium t-butoxide / CH2Cl2 / 1.5 h / Ambient temperature
7: 75 percent / diisopropylethylamine / tetrahydrofuran / 4.5 h
View Scheme
参考文献
Lewis; Revankar; Hogan
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1309 - 1316
反应条件
in N,N-dimethyl-formamide
T=80°C; Alkylation; desilylation;
参考文献
Ohta, Nobuaki; Tanaka, Noriyuki; Ito, Sotaro
Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 11 p. 2597 - 2602
反应条件
iodine in 1,2-dichloro-ethane
36 h; Heating;
参考文献
Malik, Vaishali; Singh, Palwinder; Kumar, Subodh
Tetrahedron, 2005 , vol. 61, # 16 p. 4009 - 4014
反应条件
in tetrahydrofuran
72 h; Inert atmosphereReflux;
参考文献
Kociok-Koehn, Gabriele; Mahon, Mary F.; Molloy, Kieran C.; Price, Gareth J.; Prior, Timothy J.; Smith, Douglas R. G.
Dalton Transactions, 2014 , vol. 43, # 21 p. 7734 - 7746
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile
T=-30 - 20°C; Further byproducts given;
参考文献
Gauthier, Christine; Ramondenc, Yvan; Ple, Gerard
Tetrahedron, 2001 , vol. 57, # 35 p. 7513 - 7517
反应条件
1: With triethylamine in dichloromethane
T=0 - 20°C; 72 h;
2: With ethanol; water in dichloromethane
参考文献
ALT SOLUTIONS, INC.
Patent: WO2007/106561 A2, 2007 ;
Location in patent: Page/Page column 59-60 ;
反应条件
1: 2.) hydrolyse
2: K2CO3 / dimethylformamide / 70 °C
View Scheme
参考文献
Decout; Lhomme
Tetrahedron Letters, 1981 , vol. 22, # 13 p. 1247 - 1250
