2-(4-硝基苯基)-1H-苯并咪唑合成路线 （共 52 条）
反应条件
1: 4-nitro-aniline With hydrogenchloride; sodium nitrite in water
Cooling;
2: 1H-benzo[d]imidazole With sodium acetate in water
T=20°C; 51 h; Cooling;
参考文献
Sharma, Deepika; Narasimhan, Balasubramanian; Kumar, Pradeep; Jalbout, Abraham
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 3 p. 1119 - 1127
反应条件
in N,N-dimethyl-formamide
T=150°C;
参考文献
Loennqvist, Jan-Erik; Holmstroem, Toni; Jalander, Lars F.
Journal of Chemical Research, Miniprint, 2002 , # 1 p. 154 - 161
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 24 h; Inert atmosphere;
参考文献
Zhu, Chen; Akiyama, Takahiko
Synlett, 2011 , # 9 art. no. Y03711ST, p. 1251 - 1254
反应条件
1,3,2-benzodithiazole 1,1,3,3-tetraoxide in tetrahydrofuran
9 h; RefluxGreen chemistry;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Dughera, Stefano
Arkivoc, 2012 , vol. 2012, # 9 p. 262 - 279
反应条件
1: alcohol
2: glacial acetic acid
View Scheme
参考文献
Hinsberg; Funcke
Chemische Berichte, 1894 , vol. 27, p. 2188
反应条件
1: benzene
2: sulfuric acid / 200 °C
View Scheme
参考文献
Fischer,O.; Limmer
Journal fuer Praktische Chemie (Leipzig), 1906 , vol. <2> 74, p. 59
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 70 °C
2: N,N-dimethyl-formamide / 12 h / 0 - 20 °C
3: p-toluenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Lin, Chia-Chi; Hsieh, Tsung-Han; Liao, Pen-Yuan; Liao, Zhen-Yuan; Chang, Chih-Wei; Shih, Yu-Chiao; Yeh, Wen-Hsiung; Chien, Tun-Cheng
Organic Letters, 2014 , vol. 16, # 3 p. 892 - 895
反应条件
1: N,N-dimethyl-formamide / 12 h / 0 - 20 °C
2: p-toluenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Lin, Chia-Chi; Hsieh, Tsung-Han; Liao, Pen-Yuan; Liao, Zhen-Yuan; Chang, Chih-Wei; Shih, Yu-Chiao; Yeh, Wen-Hsiung; Chien, Tun-Cheng
Organic Letters, 2014 , vol. 16, # 3 p. 892 - 895
参考文献
Itoh, Kazuyoshi; Ishida, Hideaki; Chikashita, Hidenori
Chemistry Letters, 1982 , p. 1117 - 1118
反应条件
acetic acid
T=16 - 18°C; 2 h;
参考文献
Baichurina; Baichurin; Filippenko; Aboskalova; Berestovitskaya
Russian Journal of General Chemistry, 2012 , vol. 82, # 8 p. 1400 - 1408
Zh. Obshch. Khim., 2012 , vol. 82, # 8 p. 1321 - 1329,9
