4’-甲氧基[1,1’-联苯]-4-甲酸甲酯合成路线 （共 70 条）
反应条件
potassium phosphate; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Zhao, Yu-Long; Li, You; Li, Shui-Ming; Zhou, Yi-Guo; Sun, Feng-Yi; Gao, Lian-Xun; Han, Fu-She
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1543 - 1550
反应条件
1: 4'-hydroxy-biphenyl-4-carboxylic acid With triethylamine in DMF (N,N-dimethyl-formamide) T=20°C; 0.0833333 h; 2: With potassium carbonate in DMF (N,N-dimethyl-formamide) 0.0833333 h; 3: methyl iodide in DMF (N,N-dimethyl-formamide)
参考文献
WYETH
Patent: WO2005/30702 A1, 2005 ;
Location in patent: Page/Page column 59-60 ;
反应条件
potassium phosphate; Ni(COD)2; tri-cyclo-hexyl-phosphine in tetrahydrofuran T=25°C; 8 h; Inert atmosphere;
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Patent: WO2009/137322 A2, 2009 ;
Location in patent: Page/Page column 21; 29 ;
反应条件
potassium phosphate; NiCl2(dppe); 1,2-bis-(diphenylphosphino)ethane in 1,4-dioxane T=110°C; Suzuki-Miyaura cross-coupling; 18 h; Inert atmosphere;
参考文献
Rosen, Brad M.; Huang, Chenghong; Percec, Virgil
Organic Letters, 2008 , vol. 10, # 12 p. 2597 - 2600
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; (9-phenanthrenyl)Ni(II)(PPh3)2Cl; potassium carbonate in toluene T=110°C; Suzuki Coupling; 30 h; Inert atmosphere; Reagent/catalyst;
参考文献
Hu, Feng; Lei, Xiangyang
Tetrahedron, 2014 , vol. 70, # 25 p. 3854 - 3858
反应条件
NHC-Pd(II)-Im; tetrabutyl ammonium fluoride in toluene T=120°C; Hiyama reaction; 3 h; Inert atmosphere;
参考文献
Gu, Zheng-Song; Shao, Li-Xiong; Lu, Jian-Mei
Journal of Organometallic Chemistry, 2012 , vol. 700, p. 132 - 134
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; 2-dicyclohexylphosphino-1,1'-biphenyl in 1,4-dioxane T=110°C; Inert atmosphere;
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Patent: WO2009/137322 A2, 2009 ;
Location in patent: Page/Page column 21; 22; 29; 30; 31 ;
反应条件
potassium phosphate; Ni(COD)2; tri-cyclo-hexyl-phosphine in tetrahydrofuran T=25°C; 8 h; Inert atmosphere;
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Patent: WO2009/137322 A2, 2009 ;
Location in patent: Page/Page column 21; 29 ;
反应条件
1: p-MeOC6H4MnCl With IPr*hydrochloride; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=0°C; 0.5 h; 2: 4-Bromo-benzoic acid methyl ester in tetrahydrofuran T=0 - 25°C; 0.25 h;
参考文献
Leleu, Anne; Fort, Yves; Schneider, Raphael
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 9 p. 1086 - 1092
反应条件
KF in tetrahydrofuran
参考文献
Yale University
Patent: US6562989 B2, 2003 ;
