6,7-二氢吡咯并[2,3-c]氮杂卓-4,8(1H,5H)-二酮合成路线 （共 8 条）
反应条件
PPA; phosphorus pentoxide
T=118 - 120°C; 0.5 h;
参考文献
Kasum, Bruno; Prager, Rolf H.; Tsopelas, Chris
Australian Journal of Chemistry, 1990 , vol. 43, # 2 p. 355 - 365
反应条件
1: With sodium hydroxide in ethanol
2: With PPA; phosphorus pentoxide
参考文献
Portevin, Bernard; Golsteyn, Roy M.; Pierre, Alain; De Nanteuil, Guillaume
Tetrahedron Letters, 2003 , vol. 44, # 52 p. 9263 - 9265
反应条件
1: 97 percent / triethylamine / acetonitrile / 48 h / 20 °C
2: 98 percent / NaOH / H2O / 18 h / 20 °C
3: 81 percent / P2O5; polyphosphoric acid / 1.75 h / 0 - 105 °C
View Scheme
参考文献
Papeo, Gianluca; Posteri, Helena; Borghi, Daniela; Varasi, Mario
Organic Letters, 2005 , vol. 7, # 25 p. 5641 - 5644
反应条件
1: 89 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 20 h / Ambient temperature
2: 84 percent / H2 / 5 percent Pd/C / tetrahydrofuran / 4 h
3: 68 percent / 80 percent aq. polyphosphoric acid / 0.5 h / 100 °C
View Scheme
参考文献
Mizuno, Akira; Inomata, Norio; Miya, Mikiko; Kamei, Tomoe; Shibata, Makoto; Tatsuoka, Toshio; Yoshida, Maki; Takiguchi, Chikako; Miyazaki, Tomoko
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 2 p. 246 - 256
反应条件
1: 84 percent / H2 / 5 percent Pd/C / tetrahydrofuran / 4 h
2: 68 percent / 80 percent aq. polyphosphoric acid / 0.5 h / 100 °C
View Scheme
参考文献
Mizuno, Akira; Inomata, Norio; Miya, Mikiko; Kamei, Tomoe; Shibata, Makoto; Tatsuoka, Toshio; Yoshida, Maki; Takiguchi, Chikako; Miyazaki, Tomoko
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 2 p. 246 - 256
反应条件
1: 1.) Et3N / 1.) CH2Cl2, RT, 30 min, 2.) CH2Cl2, toluene, 0 deg C, 1 h
2: 50 percent / 3.75 N NaOH / ethanol / 18 h / Ambient temperature
3: 44 percent / polyphosphoric acid / 0.33 h / 100 °C
View Scheme
参考文献
Cho, Hidetsura; Matsuki, Shinsuke; Mizuno, Akira; Annoura, Hirokazu; Tatsuoka, Toshio
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 87 - 91
反应条件
1: 50 percent / 3.75 N NaOH / ethanol / 18 h / Ambient temperature
2: 44 percent / polyphosphoric acid / 0.33 h / 100 °C
View Scheme
参考文献
Cho, Hidetsura; Matsuki, Shinsuke; Mizuno, Akira; Annoura, Hirokazu; Tatsuoka, Toshio
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 87 - 91
反应条件
potassium permanganate in water
Ambient temperature;
参考文献
Sharma, Gurdial M.; Buyer, Jeffrey S.; Pomerantz, Mark W.
Journal of the Chemical Society, Chemical Communications, 1980 , # 10 p. 435 - 436
