2-甲氧基-N,N-二甲基-苯甲酰胺合成路线 （共 13 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium
1.) THF, -90 deg C,; Yield given. Multistep reaction;
参考文献
Watanabe, Mitsuaki; Sahara, Masanori; Kubo, Masaki; Furukawa, Sunao; Billedeau, R. J.; Snieckus, V.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 742 - 747
反应条件
1: 1.) sec-BuLi , TMEDA / THF , cyclohexane, 1.) -90 deg C , 15 min , 2.) room temperature
2: 1.) LDA / THF, 1.) -78 deg C, 1 h ; 2.) a. -78 deg C , 4 h , b. room temperature , 4 h
3: 50percent NaOH / H2O; ethanol / 8 h / Heating
4: 94 percent / BBr3 / CH2Cl2 / 1.) -78 deg C , 1 h , 2.) -78 deg C to RT , 12 h
View Scheme
参考文献
Watanabe, M.; Sahara, M.; Furukawa, S.; Billedeau, R.; Snieckus, V.
Tetrahedron Letters, 1982 , vol. 23, # 16 p. 1647 - 1650
反应条件
1: 1.) sec-BuLi , TMEDA / THF , cyclohexane, 1.) -90 deg C , 15 min , 2.) room temperature
2: 1.) LDA / THF, 1.) -78 deg C, 1 h ; 2.) a. -78 deg C , 4 h , b. room temperature , 4 h
3: 50percent NaOH / H2O; ethanol / 8 h / Heating
4: 30 percent / AlCl3 / nitrobenzene / 1 h / 80 °C
View Scheme
参考文献
Watanabe, Mitsuaki; Sahara, Masanori; Kubo, Masaki; Furukawa, Sunao; Billedeau, R. J.; Snieckus, V.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 742 - 747
