4-氟-DL-alpha-苯甘氨酸合成路线 （共 18 条）
反应条件
sodium tetrahydroborate; nickel; sodium hydroxide in methanol; water T=20 - 30°C;
参考文献
Liu, Shouxin; Yang, Yihua; Zhen, Xiaoli; Li, Junzhang; He, Huimin; Feng, Juan; Whiting, Andrew
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 3 p. 663 - 670
反应条件
sodium hydroxide; hydrazine hydrate; palladium on activated charcoal in water Hydrogenolysis; 10 h; Heating;
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
1: K2CO3 / benzyltriethylammonium chloride / acetonitrile / Heating 2: 20percent aq. KOH / methanol / 2 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 1 p. 420 - 423
反应条件
1: Na2S2O5 / methanol; H2O / 2 h / 35 °C 2: 95 percent / aq. H2O2; K2CO3 / dimethylsulfoxide / 16.5 h / 21 - 35 °C 3: 89 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating 4: 77 percent / hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 30, # 6 p. 1095 - 1102
反应条件
1: 95 percent / aq. H2O2; K2CO3 / dimethylsulfoxide / 16.5 h / 21 - 35 °C 2: 89 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating 3: 77 percent / hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 30, # 6 p. 1095 - 1102
反应条件
1: 89 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating 2: 77 percent / hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 30, # 6 p. 1095 - 1102
反应条件
1: in methanol T=20°C; 2: With sodium tetrahydroborate; water; sodium hydroxide in methanol T=50 - 64°C;
参考文献
Synthetic Communications, , vol. 42, # 17 p. 2540 - 2554
反应条件
hydrogenchloride 18 h;
参考文献
Sprung; Kobow; Schulz
Pharmazie, 1989 , vol. 44, # 8 p. 540 - 542
反应条件
1: 84 percent / conc. H2SO4 2: 79 percent / conc. HCl / 18 h View Scheme
参考文献
Pharmazie, , vol. 44, # 8 p. 540 - 542
反应条件
Hydrolysis; Alkaline hydrolysis;
参考文献
Synthetic Communications, , vol. 30, # 6 p. 1095 - 1102
