(R)-1-Boc-吡咯烷-3-甲酸合成路线 （共 27 条）
反应条件
sodium hydroxide in methanol; water T=20°C; 2 h;
参考文献
Murphy, John A.; Tripoli, Regis; Khan, Tanweer A.; Mali, Umesh W.
Organic Letters, 2005 , vol. 7, # 15 p. 3287 - 3289
反应条件
triethylamine; palladium on charcoal in acetic acid
反应条件
1: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate 2: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
1: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating 2: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate 3: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
1: 99 percent / methanol / Heating 2: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating 3: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate 4: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
1: 73 percent / CH2Cl2 / 16 h / 20 °C 2: aq. NaOH / methanol / 0.25 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 7 p. 2052 - 2059
反应条件
1: 73 percent / CH2Cl2 / 16 h / 20 °C 2: aq. NaOH / methanol / 0.25 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 7 p. 2052 - 2059
反应条件
1: C57H59O5P2Rh; hydrogen / toluene / 60 h / 45 °C / 22502.3 Torr 2: Cornforth reagent / N,N-dimethyl-formamide; toluene / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 15 p. 6607 - 6616
反应条件
hydrogenchloride in water
参考文献
Chikkali, Samir H.; Bellini, Rosalba; De Bruin, Bas; Van Der Vlugt, Jarl Ivar; Reek, Joost N. H.
Journal of the American Chemical Society, 2012 , vol. 134, # 15 p. 6607 - 6616
反应条件
in methanol; hexanes; toluene 2 h;
参考文献
WO2007/70398 A1, ;
Page/Page column 188 ;
WO 2007/070398 A1
