(R)-1-Boc-吡咯烷-3-甲酸合成路线 （共 27 条）
反应条件
lipase ICR-102 in tert-butyl methyl ether T=30°C;
参考文献
Organic Process Research and Development, , vol. 13, # 2 p. 292 - 296
反应条件
lipase ICR-102 in tert-butyl methyl ether T=30°C;
参考文献
Mendiola, Javier; Garcia-Cerrada, Susana; De Frutos, Oscar; De La Puente, Maria Luz; Gu, Rui Lin; Khau, Vien V.
Organic Process Research and Development, 2009 , vol. 13, # 2 p. 292 - 296
反应条件
thionyl chloride T=20°C; Reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/5998 A1, 2009 ;
Location in patent: Page/Page column 244 ;
反应条件
hydrogenchloride in water
参考文献
Chikkali, Samir H.; Bellini, Rosalba; De Bruin, Bas; Van Der Vlugt, Jarl Ivar; Reek, Joost N. H.
Journal of the American Chemical Society, 2012 , vol. 134, # 15 p. 6607 - 6616
反应条件
hydrogenchloride in water
参考文献
Chikkali, Samir H.; Bellini, Rosalba; De Bruin, Bas; Van Der Vlugt, Jarl Ivar; Reek, Joost N. H.
Journal of the American Chemical Society, 2012 , vol. 134, # 15 p. 6607 - 6616
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
ROTTAPHARM S.P.A.; BORRIELLO, Manuela; ROVATI, Lucio; STASI, Luigi Piero; BUZZI, Benedetta; COLACE, Fabrizio
Patent: WO2012/76063 A1, 2012 ;
Location in patent: Page/Page column 54 ;
WO 2012/076063 A1
反应条件
1: With borane-THF in tetrahydrofuran T=20 - 55°C; 3 h; 2: With hydrogenchloride in tetrahydrofuran; water T=0 - 20°C;
参考文献
WO2011/150198 A1, ;
Page/Page column 151 ;
WO 2011/150198 A1
反应条件
1: Et3N / CH2Cl2 / 0 - 20 °C 2: NH3 / CH2Cl2 View Scheme
参考文献
MacLeod; Baker; Freedman; Patel; Merchant; Roe; Saunders
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 2052 - 2059
参考文献
Boga, Sobhana B.; Alhassan, Abdul-Basit; Cooper, Alan B.; Shih, Neng-Yang; Doll, Ronald J.
Tetrahedron Letters, 2009 , vol. 50, # 38 p. 5315 - 5316
反应条件
in methanol; hexane; toluene T=0 - 20°C; 0.166667 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/153858 A1, 2008 ;
Location in patent: Page/Page column 221 ;
WO 2008/153858 A1
