反应条件
1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C
2: diethyl ether; tetrahydrofuran / 2.5 h / -78 - 0 °C
View Scheme
参考文献
Hill, Pamela J.; Abibi, Ayome; Albert, Robert; Andrews, Beth; Gagnon, Moriah M.; Gao, Ning; Grebe, Tyler; Hajec, Laurel I.; Huang, Jian; Livchak, Stephania; Lahiri, Sushmita D.; McKinney, David C.; Thresher, Jason; Wang, Hongming; Olivier, Nelson; Buurman, Ed T.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7278 - 7288