1-(4-氯苯基)-1-环丙烷羧酸合成路线 （共 6 条）
反应条件
sulfuric acid; water Reflux;
参考文献
RELIANCE LIFE SCIENCES PVT. LTD.
Patent: WO2009/150660 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
2: aq. KOH / ethanol View Scheme
参考文献
Chemische Berichte, , vol. 112, p. 3914 - 3933
反应条件
1: With diphenyl phosphoryl azide; triethylamine in N,N-dimethyl-formamide T=20 - 100°C; 18 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide
参考文献
Boehringer Ingelheim International GmbH
Patent: US2006/116370 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
in tetrahydrofuran; nitrogen
参考文献
Zhuo, Jincong; Li, Yun-Long; Xu, Meizhong; He, Chunhong; Yao, Wenqing
Patent: US2007/208001 A1, 2007 ;
Location in patent: Page/Page column 33 ;
US 20070208001 A1
反应条件
thionyl chloride
T=20°C; 1 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/141119 A2, 2008 ;
Location in patent: Page/Page column 160 ;
WO 2008/141119 A2
反应条件
1: H2SO4; KNO3 / 16 h / 0 - 20 °C
2: DPPA / tetrahydrofuran / 3 h / Heating
3: TFA / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Leonard, Kristi; Marugan, Juan Jose; Raboisson, Pierre; Calvo, Raul; Gushue, Joan M.; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3463 - 3468
