1.1: n-butyllithium / hexane; tert-butyl methyl ether / 3.5 h / 0 - 3 °C / Industry scale 1.2: 1.5 h / 2 °C / Industry scale 2.1: hydrogenchloride; water / tert-butyl methyl ether / 1 h / 22 - 25 °C / pH 0.5 - 0.6 / Industry scale 2.2: 0.25 h / 22 - 30 °C / pH >= 12 / Industry scale 3.1: N-ethyl-N,N-diisopropylamine / tert-butyl methyl ether / 1 h / 2 °C / Industry scale 4.1: tetramethyl guanidine / isopropyl alcohol / 1.5 h / 70 °C / Industry scale 4.2: 22 °C / pH <= 1.5 / Industry scale View Scheme

1.1: n-butyllithium / hexane; tert-butyl methyl ether / 3.5 h / 0 - 3 °C / Industry scale 1.2: 1.5 h / 2 °C / Industry scale 2.1: hydrogenchloride; water / tert-butyl methyl ether / 1 h / 22 - 25 °C / pH 0.5 - 0.6 / Industry scale 2.2: 0.25 h / 22 - 30 °C / pH >= 12 / Industry scale 3.1: N-ethyl-N,N-diisopropylamine / tert-butyl methyl ether / 1 h / 2 °C / Industry scale 4.1: tetramethyl guanidine / isopropyl alcohol / 1.5 h / 70 °C / Industry scale 4.2: 22 °C / pH <= 1.5 / Industry scale 5.1: benzotriazol-1-ol; 4-methyl-morpholine; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide / acetonitrile; water / 5 h / 5 - 40 °C / Industry scale 6.1: sodium hydroxide; water / 2-methyl tetrahydrofuran / 7 h / 20 - 60 °C / Industry scale 6.2: 0.17 h / 20 - 30 °C / pH 1.5 - 3 / Industry scale View Scheme

1.1: n-butyllithium / hexane; tert-butyl methyl ether / 3.5 h / 0 - 3 °C / Industry scale 1.2: 1.5 h / 2 °C / Industry scale 2.1: hydrogenchloride; water / tert-butyl methyl ether / 1 h / 22 - 25 °C / pH 0.5 - 0.6 / Industry scale 2.2: 0.25 h / 22 - 30 °C / pH >= 12 / Industry scale 3.1: N-ethyl-N,N-diisopropylamine / tert-butyl methyl ether / 1 h / 2 °C / Industry scale 4.1: tetramethyl guanidine / isopropyl alcohol / 1.5 h / 70 °C / Industry scale 4.2: 22 °C / pH <= 1.5 / Industry scale 5.1: benzotriazol-1-ol; 4-methyl-morpholine; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide / acetonitrile; water / 5 h / 5 - 40 °C / Industry scale 6.1: sodium hydroxide; water / 2-methyl tetrahydrofuran / 7 h / 20 - 60 °C / Industry scale 6.2: 0.17 h / 20 - 30 °C / pH 1.5 - 3 / Industry scale 7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide / ethyl acetate; acetonitrile; water / -5 - 30 °C / Industry scale 8.1: sodium acetate; sodium hypochlorite; acetic acid; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / methyl acetate; water; tert-butyl methyl ether / 2 h / 5 - 15 °C / Industry scale View Scheme

1: tetrahydrofuran / 2.5 h / -78 - 20 °C / |Inert atmosphere 2: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C / |Inert atmosphere 3: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 0 - 20 °C / |Inert atmosphere 4: tri-ruthenium(0)dodecacarbonyl; tetra-(n-butyl)ammonium iodide; carbon monoxide / N,N-dimethyl-formamide / 4 h / 150 °C / |Autoclave View Scheme