1.1: 77 percent / DPPF; Et3N; HCOO2H / Pd(OAc)2 / dimethylformamide / 24 h / 80 °C 2.1: 89 percent / Na; NpH / 1,2-dimethoxy-ethane / -56 °C 3.1: H2O; methanol / 0.5 h / 20 °C 3.2: 84 percent / NaBH4 / 1 h / 20 °C View Scheme

1: 77 percent / DPPF; Et3N; HCOO2H / Pd(OAc)2 / dimethylformamide / 24 h / 80 °C 2: 89 percent / Na; NpH / 1,2-dimethoxy-ethane / -56 °C View Scheme