[4-(3-氯苯基)哌嗪-1-基](5-甲基-2-苯基-2H-吡唑-3-基)甲酮合成路线 (共 1 条)
反应条件
1: 3-methyl-1-phenyl-1H-pyrazole-5-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 3 h;
2: 1-(3-chloro-phenyl)-piperazine With triethylamine in tetrahydrofuran
T=20°C; 18 h;
参考文献
Aventis Pharma S. A.
Patent: US2005/130989 A1, 2005 ;
Location in patent: Page/Page column 12; 13 ;