2-羟基-5-乙酰氨基苯乙酮合成路线 （共 25 条）
反应条件
AlCl3, aluminium chloride in carbon disulfide Friedel Crafts acylation; 1.5 h;
参考文献
UNIVERSITE DE LIEGE; UNIVERSITE LIBRE DE BRUXELLES; GOFFIN, Eric; DE TULLIO, Pascal; FLORENCE, Xavier; PIROTTE, Bernard; ROGISTER, Bernard; LAMORAL-THEYS, Delphine; LEFRANC, Florence; KISS, Robert
Patent: WO2012/107262 A1, 2012 ;
Location in patent: Page/Page column 29 ;
反应条件
ytterbium trifluoromethanesulfonate; lithium perchlorate in nitromethane T=100°C; Fries rearrangement; 8 h;
参考文献
Su, Weike; Jin, Can
Journal of Chemical Research, 2004 , # 9 p. 611 - 613
反应条件
aluminium trichloride in nitrobenzene T=20 - 130°C; 3 h;
参考文献
Kettmann; Csollei; Racanska; Svec
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 9 p. 843 - 851
反应条件
1: hydrogen / 5percent Pd/C / tetrahydrofuran / 2 h / 2068.6 Torr 2: tetrahydrofuran / 0.33 h / 60 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 20 p. 3353 - 3362
反应条件
1: 33 percent / nitric acid, glacial acetic acid / 1.) RT, 40 min, 2.) from 45 to 50 deg C, 16 h 2: hydrogen / 5percent Pd/C / tetrahydrofuran / 2 h / 2068.6 Torr 3: tetrahydrofuran / 0.33 h / 60 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 20 p. 3353 - 3362
反应条件
water; sodium hydroxide
参考文献
EP2487171 A1, ;
Page/Page column 13 ;
反应条件
1: sodium acetate; acetic acid 2: AlCl3, aluminium chloride / carbon disulfide / 1.5 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 13 p. 3919 - 3928
反应条件
in tetrahydrofuran T=60°C; 0.333333 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 20 p. 3353 - 3362
反应条件
1: 52 percent / pyridine / CH2Cl2 / 5 °C 2: 10 percent / aluminium chloride / 2 h / 140 °C View Scheme
参考文献
Pharmacy and Pharmacology Communications, , vol. 5, # 5 p. 323 - 329
反应条件
1: AlCl3, aluminium chloride / carbon disulfide / 1.5 h / 80 - 90 °C 2: sodium hydroxide; water View Scheme
