3-(苯基甲基)-1,3-二氮杂螺[4.5]癸烷-2,4-二酮合成路线 （共 8 条）
反应条件
lithium hydroxide in tetrahydrofuran
T=0 - 20°C; 3 h;
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
potassium hydroxide in ethanol
24 h; Heating;
参考文献
Pedregal; Trigo; Espada; et al.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 2 p. 477 - 480
反应条件
1: thionyl chloride
2: sodium azide / toluene / 1 h / Heating
3: CHCl3 / 3 h / 0 - 20 °C
4: 78 percent / aq. lithium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C
View Scheme
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
1: hydrogen chloride gas / Heating
2: CHCl3 / 3 h / 0 - 20 °C
3: 78 percent / aq. lithium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C
View Scheme
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
1: CHCl3 / 3 h / 0 - 20 °C
2: 78 percent / aq. lithium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C
View Scheme
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
1: CHCl3 / 3 h / 0 - 20 °C
2: 78 percent / aq. lithium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C
View Scheme
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
1: sodium azide / toluene / 1 h / Heating
2: CHCl3 / 3 h / 0 - 20 °C
3: 78 percent / aq. lithium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C
View Scheme
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
sodium hydroxide
1) EtOH, reflux, 15 min; 2) reflux, 24 h; Yield given. Multistep reaction;
参考文献
Salazar, Loreto; Rubido, Julia; Espada, Modesta; Pedregal, Carmen; Trigo, Gregorio; Elguero, Jose
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 481 - 485
