4-(8,9-二氢吡啶并[2,3-b]-1,6-萘啶-7(6H)-基)-4-氧代丁酸合成路线 （共 3 条）
反应条件
sodium hydroxide; water in methanol 2.5 h;
参考文献
WO2009/4350 A1, ;
Page/Page column 12; 13 ;
反应条件
1: lithium hydroxide hydrate / tetrahydrofuran; water / 3 h / 0 °C 2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Milo, Lawrence J.; Lai, Jack H.; Wu, Wengen; Liu, Yuxin; Maw, Hlaing; Li, Youhua; Jin, Zhiping; Shu, Ying; Poplawski, Sarah E.; Wu, Yong; Sanford, David G.; Sudmeier, James L.; Bachovchin, William W.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4365 - 4377
反应条件
sodium hydroxide in 1,4-dioxane; methanol 1 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 5, # 9 p. 1416 - 1426
