1-(2-羟基乙基)环戊醇合成路线 （共 8 条）
反应条件
zirconium orthophosphate T=305°C; Dehydration; 15 h; Product distribution; Further Variations:Reagents;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 7 p. 1421 - 1423
反应条件
1: 1,4-dibromo-butane With iodine; magnesium in tetrahydrofuran
T=20°C; 3 h;
2: β-propiolactone in tetrahydrofuran
T=20°C; 12 h;
3: With ammonium chloride in tetrahydrofuran
参考文献
ABBOTT LABORATORIES
Patent: US2010/249129 A1, 2010 ;
Location in patent: Page/Page column 51-52 ;
US 20100249129 A1
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Carr, Graham; Whittaker, David
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 359 - 366
反应条件
lithium aluminium tetrahydride
参考文献
Papa et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 4441,4445
反应条件
1: 79 percent / tetrahydrofuran / 15 h / 0 °C
2: 200 mg / KHF2, TFA / CHCl3 / 18 h / Ambient temperature
3: NaHCO3, H2O2 / tetrahydrofuran; methanol / 18 h / Heating
View Scheme
参考文献
Klos, Andrew M.; Heintzelman, Geoffrey R.; Weinreb, Steven M.
Journal of Organic Chemistry, 1997 , vol. 62, # 11 p. 3758 - 3761
反应条件
1: 200 mg / KHF2, TFA / CHCl3 / 18 h / Ambient temperature
2: NaHCO3, H2O2 / tetrahydrofuran; methanol / 18 h / Heating
View Scheme
参考文献
Klos, Andrew M.; Heintzelman, Geoffrey R.; Weinreb, Steven M.
Journal of Organic Chemistry, 1997 , vol. 62, # 11 p. 3758 - 3761
反应条件
1: With sodium hydride in tetrahydrofuran
T=20°C; Horner-Wadsworth-Emmons reaction;
2: With 3-chloro-benzenecarboperoxoic acid in chloroform
T=20°C;
3: With lithium aluminium tetrahydride in tetrahydrofuran
T=20°C;
参考文献
Satoh, Tsuyoshi; Yasoshima, Tsukasa; Momochi, Hitoshi
Tetrahedron Letters, 2012 , vol. 53, # 16 p. 2074 - 2077
反应条件
in tetrahydrofuran
also investigated: reaction with BrMg(CH2)5MgBr; other lactones; Mechanism;
参考文献
Canonne, Persephone; Foscolos, Georges B.; Belanger, Denis
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1828 - 1835
