(6Z,9Z,12Z,15Z)-十八碳四烯酸甲酯合成路线 （共 3 条）
反应条件
1.1: 92 percent / LiAlH4 / diethyl ether / 2 h / 20 °C 2.1: 88 percent / Ph3PBr2 / CH2Cl2 / 0.5 h / 20 °C 3.1: n-BuLi / hexane; tetrahydrofuran / 0.08 h / -78 °C 3.2: 2.686 g / hexane; tetrahydrofuran / 2.33 h / -78 °C 4.1: 91 percent / AcCl / 12 h / Heating View Scheme
参考文献
Kuklev, Dmitry V.; Smith, William L.
Chemistry and Physics of Lipids, 2006 , vol. 144, # 2 p. 172 - 177
反应条件
1.1: 92 percent / LiAlH4 / diethyl ether / 2 h / 20 °C 2.1: 88 percent / Ph3PBr2 / CH2Cl2 / 0.5 h / 20 °C 3.1: n-BuLi / hexane; tetrahydrofuran / 0.08 h / -78 °C 3.2: 2.686 g / hexane; tetrahydrofuran / 2.33 h / -78 °C 4.1: 91 percent / AcCl / 12 h / Heating 5.1: 93 percent / aq. KOH / ethanol / 16 h / 20 °C View Scheme
参考文献
Kuklev; Popkov; Kas'yanov; Akulin; Bezuglov
Russian Journal of Bioorganic Chemistry, 1996 , vol. 22, # 3 p. 192 - 195
反应条件
potassium hydroxide in methanol; water T=50°C; 1.5 h; Inert atmosphere; regioselective reaction;
参考文献
Jakobsen, Martin Gjerde; Vik, Anders; Hansen, Trond Vidar
Tetrahedron Letters, 2012 , vol. 53, # 44 p. 5837 - 5839
