1,2-苯并异唑-3-甲磺酸钠盐合成路线 （共 8 条）
反应条件
sodium hydroxide in monoethyleneglycol T=25 - 90°C; 3 h; Heating; Product distribution / selectivity;
参考文献
SUVEN LIFE SCIENCES LIMITED
Patent: WO2005/30738 A1, 2005 ;
Location in patent: Page/Page column 16-17 ;
反应条件
sodium sulfite in methanol; water T=50°C; 4 h;
参考文献
US2006/9644 A1, ;
Page/Page column 9 ;
反应条件
1: With chlorosulfonic acid in 1,2-dichloro-ethane T=63 - 79°C; 1.5 h; 2: With sodium hydroxide in water; 1,2-dichloro-ethane pH=>= 11;
参考文献
US2005/215796 A1, ;
Page/Page column 3 ;
反应条件
1: 30 percent / H2 / 5percent Pd-C / ethanol 2: 89 percent / hydroxylamine / ethanol / 3 h / Heating 3: 5percent Na2CO3 / 3 h / 95 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 1 p. 333 - 335
反应条件
sodium carbonate T=95°C; 3 h;
参考文献
Uno; Kurokawa
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 1 p. 333 - 335
反应条件
1: 89 percent / hydroxylamine / ethanol / 3 h / Heating 2: 5percent Na2CO3 / 3 h / 95 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 1 p. 333 - 335
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene T=25 - 50°C; 6 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/16209 A2, 2007 ;
Location in patent: Page/Page column 13 ;
反应条件
1: in DMF (N,N-dimethyl-formamide); toluene T=10 - 40°C; 2 h; 2: With oxalyl dichloride in DMF (N,N-dimethyl-formamide); toluene T=10 - 18°C; 2 h; 3: With ammonia in DMF (N,N-dimethyl-formamide); toluene T=10 - 18°C; 2 h; Product distribution / selectivity;
参考文献
US2006/9644 A1, ;
Page/Page column 10 ;
