(E)-2-(4-溴苯基)-3-环己基-2-丙烯-1-醇合成路线 （共 3 条）
反应条件
diisobutylaluminium hydride in toluene
T=-78 - 20°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/63179 A1, 2004 ;
Location in patent: Page 86 ;
WO 2004/063179 A1
反应条件
1.1: 72 percent / AlCl3 / CH2Cl2 / 4 h / -10 - 20 °C
2.1: 80 percent / LiHMDS / tetrahydrofuran / 16 h / 0 - 20 °C
3.1: NaOMe / methanol / 16 h / 50 °C
3.2: 75 percent / NaOH / methanol; H2O / 5 h / 50 °C
4.1: 86 percent / DIBAH / toluene / 16 h / -70 - 20 °C
View Scheme
参考文献
Heuser, Stefan; Barrett, David G.; Berg, Martina; Bonnier, Benjamin; Kahl, Astrid; De La Puente, Maria Luz; Oram, Niall; Riedl, Rainer; Roettig, Ulrike; Gil, Gema Sanz; Seger, Erich; Steggles, David J.; Wanner, Jutta; Weichert, Andreas G.
Tetrahedron Letters, 2006 , vol. 47, # 16 p. 2675 - 2678
反应条件
1.1: 80 percent / LiHMDS / tetrahydrofuran / 16 h / 0 - 20 °C
2.1: NaOMe / methanol / 16 h / 50 °C
2.2: 75 percent / NaOH / methanol; H2O / 5 h / 50 °C
3.1: 86 percent / DIBAH / toluene / 16 h / -70 - 20 °C
View Scheme
参考文献
Heuser, Stefan; Barrett, David G.; Berg, Martina; Bonnier, Benjamin; Kahl, Astrid; De La Puente, Maria Luz; Oram, Niall; Riedl, Rainer; Roettig, Ulrike; Gil, Gema Sanz; Seger, Erich; Steggles, David J.; Wanner, Jutta; Weichert, Andreas G.
Tetrahedron Letters, 2006 , vol. 47, # 16 p. 2675 - 2678
