N-(5-氟-2-噻唑)-氨基甲酸-1,1-二甲基乙酯合成路线 （共 9 条）
参考文献
Li, Fuying; Zhu, Qingzhang; Zhang, Yi; Feng, Ying; Leng, Ying; Zhang, Ao
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 11 p. 3875 - 3884
反应条件
hydrogenchloride in 1,4-dioxane T=35°C; 5 h; Large scale;
参考文献
Briner, Paul H.; Fyfe, Matthew C. T.; Martin, Pierre; Murray, P. John; Naud, Frederic; Procter, Martin J.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 346 - 348
反应条件
Selectfluorreg;; K3PO4 in 2-methyl tetrahydrofuran; water
T=2 - 20°C; 3 h;
参考文献
TAKEDA SAN DIEGO, INC.; MATTSON, Matthew
Patent: WO2011/115758 A1, 2011 ;
Location in patent: Page/Page column 14 ;
反应条件
1: With tert.-butyl lithium in tetrahydrofuran; pentane
T=-50°C; 0.5 h; Large scale;
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; pentane
T=-50°C; 0.5 h; Large scale;
参考文献
Briner, Paul H.; Fyfe, Matthew C. T.; Martin, Pierre; Murray, P. John; Naud, Frederic; Procter, Martin J.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 346 - 348
反应条件
n-butyllithium; N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran
T=-78 - 20°C;
参考文献
Cheruvallath, Zacharia; Feng, Jun; Guntupalli, Prasuna; Gwaltney, Stephen L.; Kaldor, Stephen W.; Miura, Joanne; Sabat, Mark; Tang, Mingnam; Wolgast, Beverly
Patent: US2007/213349 A1, 2007 ;
Location in patent: Page/Page column 67 ;
US 20070213349 A1
反应条件
1: With tert.-butyl lithium
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide
参考文献
Briner, Paul H.; Fyfe, Matthew C. T.; Martin, Pierre; Murray, P. John; Naud, Frederic; Procter, Martin J.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 346 - 348
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 16 h / 20 °C
2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 60 °C
2.2: pH 1 - 2
3.1: Selectfluorreg;; K3PO4 / water; 2-methyl tetrahydrofuran / 3 h / 2 - 20 °C
View Scheme
参考文献
TAKEDA SAN DIEGO, INC.; MATTSON, Matthew
Patent: WO2011/115758 A1, 2011 ;
反应条件
1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 60 °C
1.2: pH 1 - 2
2.1: Selectfluorreg;; K3PO4 / water; 2-methyl tetrahydrofuran / 3 h / 2 - 20 °C
View Scheme
参考文献
TAKEDA SAN DIEGO, INC.; MATTSON, Matthew
Patent: WO2011/115758 A1, 2011 ;
反应条件
1: With tert.-butyl lithium
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide
参考文献
Briner, Paul H.; Fyfe, Matthew C. T.; Martin, Pierre; Murray, P. John; Naud, Frederic; Procter, Martin J.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 346 - 348
