3,5-二甲氧基苯甲醛合成路线 （共 226 条）
反应条件
piperidine; benzoic acid in toluene 1 h; Reflux;
参考文献
Hwang, Ki-Jun; Shin, Young-Min; Kim, Dae-Hyuk; Kim, Beom-Tae
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 9 p. 3095 - 3098
反应条件
1: aq. HCl / tetrahydrofuran / -20 °C 2: PCC / CH2Cl2 / 20 °C 3: BF3*Et2O / CH2Cl2 / 20 °C 4: Raney-Ni / ethanol; ethyl acetate / Heating 5: BBr3 / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Krishnamurthy, Mathangi; Ferreira, Antonio M.; Moore II, Bob M.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3487 - 3490
参考文献
Billman; Koehler; May
Journal of pharmaceutical sciences, 1969 , vol. 58, # 6 p. 767 - 769
反应条件
1.1: piperidinium acetate / ethanol / 0.5 h 1.2: 61 percent / NaBH3CN / ethanol / 0 - 20 °C 2.1: 73 percent / Sc(OTf)3 / nitromethane / 1 h / 100 °C View Scheme
参考文献
Fillion, Eric; Fishlock, Dan
Organic Letters, 2003 , vol. 5, # 24 p. 4653 - 4656
反应条件
sodium tetrahydroborate 1) r.t., overnight, EtOH-water, 2) 1 h, EtOH-water; Yield given. Multistep reaction;
参考文献
Hamada; Okuno; Ohmori; et al.
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 128 - 136
反应条件
sodium methylate 1.) DMF, 0 deg C, 30 min, 2.) a) DMF, from 0 deg C to RT, 1.5 h, b) 95-100 deg C, 1 h, c) RT, overnight; Multistep reaction;
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Chakraborti, Asit K.; Lin, Chii M.; Hamel, Ernest
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2579 - 2588
反应条件
n-butyllithium 1.) THF, hexane, 0 deg C, 10 min; 2.) THF, r.t., 12 h; Yield given. Multistep reaction;
参考文献
Brown; Brown, Karen M.; Lawrence; Lawrence, Nicholas J.; Liddle; Liddle, John; Muhammad; Muhammad, Faiz; Jackson; Jackson, David A.
Tetrahedron Letters, 1994 , vol. 35, # 36 p. 6733 - 6736
反应条件
N-bromosuccinmide T=0°C; Solid phase reaction; bromination; 0.0416667 h;
参考文献
Sarma, Jagarlapudi A.R.P.; Nagaraju, Akula; Majumdar, Kanak K.; Samuel, Purnima M.; Das, Indira; Roy, Sujit; McGhie, Alistair J.
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 6 p. 1119 - 1123
反应条件
1: acetic acid; bromine 2: acetic acid; bromine 3: concentrated aqueous KOH View Scheme
参考文献
Lock; Nottes
Monatshefte fuer Chemie, 1936 , vol. 68, p. 51,60
反应条件
phosphorus tribromide in dichloromethane 1 h; Ambient temperature; Yield given;
参考文献
Jamie, Joanne F.; Rickards, Rodney W.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 21 p. 2603 - 2613
