3,5-二甲氧基苯甲醛合成路线 （共 226 条）
反应条件
sodium perborate in acetic acid T=45 - 50°C; 8 h;
参考文献
McKillop, Alexander; Kemp, Duncan
Tetrahedron, 1989 , vol. 45, # 11 p. 3299 - 3306
反应条件
potassium hydroxide T=100°C; solvent-free Cannizzaro reaction; 0.0833333 h;
参考文献
Tetrahedron Letters, , vol. 42, # 45 p. 7983 - 7985
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 2.1: triethylamine; chloro-trimethyl-silane; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 0.25 h / 0 - 20 °C 2.2: 0.5 h / 20 °C / |Cooling with ice 3.1: (8-oxyquinolinate)2VV(O)(OiPr) / pyridine-D5 / 48 h / 100 °C View Scheme
参考文献
Sedai, Baburam; Diaz-Urrutia, Christian; Baker, R. Tom; Wu, Ruilian; Silks, L. A. Pete; Hanson, Susan K.
ACS Catalysis, 2013 , vol. 3, # 12 p. 3111 - 3122
反应条件
potassium cyanide; water T=80°C; 24 h;
参考文献
Bulletin of the Korean Chemical Society, , vol. 32, # 6 p. 2070 - 2072
反应条件
1.1: Mg / tetrahydrofuran / 1 h / Heating 1.2: 93 percent / tetrahydrofuran / -78 - 20 °C 2.1: TMSCl; NaI / acetonitrile; hexane; diethyl ether / 24 h / 20 °C 3.1: 1.236 g / BBr3 / CH2Cl2 / 36 h / 20 °C 4.1: 37.5 percent / MgSO4; BF3*Et2O / CH2Cl2 / 2.5 h / 0 °C 5.1: 47 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7389 - 7399
反应条件
1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C 2: phosphorus tribromide; pyridine / dichloromethane / 4 h / 0 - 20 °C 3: 10 h / 120 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 24 p. 7683 - 7687
反应条件
1: 93 percent / BH3*THF / tetrahydrofuran / 12 h 2: 70 percent / methanesulfonyl chloride; triethylamine 3: 1-methyl-pyrrolidin-2-one / 5 h View Scheme
参考文献
Adams; Aycock; Loewe
Journal of the American Chemical Society, 1948 , vol. 70, p. 662
反应条件
1: toluene / 5 h / Inert atmosphere; Reflux 2: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere View Scheme
参考文献
Smith, Laura H. S.; Nguyen, Trung Thanh; Sneddon, Helen F.; Procter, David J.
Chemical Communications, 2011 , vol. 47, # 38 p. 10821 - 10823
反应条件
2: H2 / Pd/C / H2O / pH<7 3: BBr3 View Scheme
参考文献
Wenkert,E. et al.
Journal of Organic Chemistry, 1964 , vol. 29, p. 435 - 439
反应条件
1: n-butyllithium / tetrahydrofuran / 12 h / 20 °C 2: palladium on carbon; hydrogen / methanol / 12 h / 20 °C 3: boron tribromide / dichloromethane / 12 h / -40 - 20 °C View Scheme
参考文献
Mizuno, Cassia S.; Rimando, Agnes M.; Duke, Stephen O.
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 7 p. 4353 - 4355
