3,5-二甲氧基苯甲醛合成路线 （共 226 条）
反应条件
1: 93 percent / BH3*THF / tetrahydrofuran / 12 h 2: 70 percent / methanesulfonyl chloride; triethylamine 3: 1-methyl-pyrrolidin-2-one / 5 h 4: HCl / H2O / 5 h / 70 °C View Scheme
参考文献
Mannila, Erkki; Talvitie, Antti
Liebigs Annalen der Chemie, 1993 , # 9 p. 1037 - 1040
反应条件
1: 1.) n-butyl Li / 1.) THF, hexane, 30 min; 2.) 0 deg C, THF, 30 min 2: 100 percent / hydrogen / 5percent Pd-C / ethanol / 1 h / Ambient temperature 3: 90 percent / BBr3 / CH2Cl2 / 1.) -70 deg C; 2.) room temperature, 1.5 h View Scheme
参考文献
Ali; Kondo; Tsuda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 5 p. 1130 - 1136
反应条件
1: 86 percent / tetrahydrofuran / 4 h / -60 °C 2: 79.6 percent / CrO3, aq. H2SO4 / acetone / 0.5 h / Ambient temperature 3: 97 percent / BF3*Et2O / CH2Cl2 / Ambient temperature 4: 84 percent / BBr3 / CH2Cl2 / 15 h / -78 - 0 °C 5: p-toluenesulfonic acid / benzene / 0.5 h / 25 °C 6: BF3*Et2O / CH2Cl2 / 4 h / 25 °C View Scheme
参考文献
Papahatjis; Kourouli; Abadji; Goutopoulos; Makriyannis
Journal of Medicinal Chemistry, 1998 , vol. 41, # 7 p. 1195 - 1200
反应条件
1: 1) tetramethylethylenediamine, sec-butyl lithium / 1) THF, pentane, -80 deg C, 20 min, 2) -80 deg C, 20 min 2: p-toluenesulfonic acid / toluene / 2 h / Ambient temperature 3: 96 percent / conc. H2SO4, H2 / 10percent Pd/C / tetrahydrofuran / 6 h / 45 °C / 3750.3 Torr 4: 95 percent / CH2Cl2 / 6 h / Ambient temperature 5: 91 percent / conc. HCl / methanol / 2 h / 45 °C View Scheme
参考文献
Monatshefte fuer Chemie, , vol. 122, # 8 p. 739 - 744
反应条件
1: 1.) N,N,N',N'-tetramethylethylenediamine, s-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 1 h 2: 99 percent / p-toluenesulfonic acid / toluene / 2 h / Heating 3: 93 percent / hydrogen / Pd/C / ethyl acetate / 48 h View Scheme
参考文献
English; Zhang; Kraus; Petrich
Journal of the American Chemical Society, 1997 , vol. 119, # 13 p. 2980 - 2986
反应条件
1: tetrahydrofuran 2: H2 / Pd-C 3: NaSEt / dimethylformamide View Scheme
参考文献
Ali; Kondo; Tsuda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 5 p. 1130 - 1136
反应条件
1.1: sec.-butyllithium / tetrahydrofuran; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 - 20 °C / Inert atmosphere 2.1: Pearlman's catalist; hydrogen / tetrahydrofuran; methanol / 20 °C 3.1: trifluoroacetic anhydride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere 3.2: 3.5 h / 20 °C 4.1: aluminium(III) iodide; tetra-(n-butyl)ammonium iodide / benzene / 12 h / Reflux; Inert atmosphere View Scheme
参考文献
Fukuda, Tsutomu; Fukushima, Koichiro; Sanai, Susumu; Iwao, Masatomo
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 1 p. 133 - 135
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate; benzyl chloride T=90°C; 0.5 h; Microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 52, # 41 p. 5319 - 5322
反应条件
potassium cyanide; water T=80°C; 24 h;
参考文献
Bulletin of the Korean Chemical Society, , vol. 32, # 6 p. 2070 - 2072
反应条件
potassium tert-butylate; diphenyldisulfane 1.) THF, 30 min, 2.) THF, reflux, 6 h; Yield given. Multistep reaction;
参考文献
Ali; Kondo; Tsuda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 5 p. 1130 - 1136
